An internal standard for the quantification of roxatidine
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Unlabeled Version(s)
36111Roxatidine
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Roxatidine-d10 (hemioxalate)

Item No. 34007

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-hydroxy-N-[3-[3-(1-piperidinyl-2,2,3,3,4,4,5,5,6,6-d10-methyl)phenoxy]propyl]-acetamide, ethanedioate (2:1)
CAS Number
2832423-41-1
Molecular Formula
C17H16D10N2O3 • 1/2C2H2O4
Formula Weight
361.5
Purity
≥99% deuterated forms (d1-d10)
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleWater: Soluble
SMILES
OCC(NCCCOC1=CC=CC(CN2C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C2([2H])[2H])=C1)=O.OC(C(O)=O)=O
InChi Code
InChI=1S/2C17H26N2O3.C2H2O4/c2*20-14-17(21)18-8-5-11-22-16-7-4-6-15(12-16)13-19-9-2-1-3-10-19;3-1(4)2(5)6/h2*4,6-7,12,20H,1-3,5,8-11,13-14H2,(H,18,21);(H,3,4)(H,5,6)/i2*1D2,2D2,3D2,9D2,10D2;
InChi Key
HCVXGACZDFYYTI-JUUMQSSDSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $202

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    5 mg

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    Product Description

    Roxatidine-d10 is intended for use as an internal standard for the quantification of roxatidine by GC- or LC-MS. Roxatidine is a histamine H2 receptor antagonist and major active metabolite of roxatidine acetate (Item No. 21248).1 Roxatidine reduces histamine-induced adenylate cyclase production in guinea pig parietal cells (IC50 = 0.8 µM). It inhibits histamine-induced hydrogen ion accumulation in the same cells (pA2 = 7.03). Roxatidine (200 mg/kg) reduces small intestinal lesion area in a rat model of gastric mucosal injury induced by indomethacin (Item No. 70270).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sewing, K.-F., Beil, W., and Hannemann, H. Comparative pharmacology of histamine H2-receptor antagonists. Drugs 35(Suppl. 3), 25-29 (1988).

    2. Umegaki, E., Yoda, Y., Tokioka, S., et al. Protective effect of roxatidine against indomethacin induced small intestinal mucosal injury in rats. J. Gastroenterol. Hepatol. 25(Suppl. 1), S35-S40 (2010).