A phenylethanoid glycoside with diverse biological activities
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Poliumoside

Item No. 34389

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3,4-dihydroxyphenyl)ethyl O-6-deoxy-α-L-mannopyranosyl-(1→3)-O-[6-deoxy-α-L-mannopyranosyl-(1→6)]-β-D-glucopyranoside, 4-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]
CAS Number
94079-81-9
Molecular Formula
C35H46O19
Formula Weight
770.7
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 5 mg/mlDMSO: 15 mg/mlPBS (pH 7.2): 10 mg/ml
λmax
219, 335 nm
SMILES
OC(C=C1/C=C/C(O[C@H]2[C@@H]([C@H]([C@@H](O[C@@H]2CO[C@H]3[C@@H]([C@@H]([C@H]([C@@H](O3)C)O)O)O)OCCC4=CC(O)=C(C=C4)O)O)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)O)O)O)=O)=C(C=C1)O
InChi Code
InChI=1S/C35H46O19/c1-14-24(41)26(43)28(45)33(50-14)49-13-22-31(53-23(40)8-5-16-3-6-18(36)20(38)11-16)32(54-35-29(46)27(44)25(42)15(2)51-35)30(47)34(52-22)48-10-9-17-4-7-19(37)21(39)12-17/h3-8,11-12,14-15,22,24-39,41-47H,9-10,13H2,1-2H3/b8-5+/t14-,15-,22+,24-,25-,26+,27+,28+,29+,30+,31+,32+,33+,34+,35-/m0/s1
InChi Key
YMWRMAOPKNYHMZ-LLVTZOIGSA-N
Origin
Plant/Callicarpa bodinieri
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $95

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    10 mg

    $168

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    25 mg

    $392

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    100 mg

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    Product Description

    Poliumoside is a phenylethanoid glycoside that has been found in C. dichotoma and has diverse biological activities.1,2,3,4 It scavenges DPPH (Item No. 14805) and ABTS (Item No. 27317) radicals (IC50s = 10.9 and 19.9 µM), as well as inhibits the activity of PKCα (IC50 = 24.4 µM), in cell-free assays.1,2 Poliumoside (12.5-100 µM) reduces LPS-induced production of TNF-α and IL-6 in RAW 264.7 cells.3 It decreases glutamate-induced cytotoxicity in primary rat cortical neurons when used at concentrations of 0.1, 1, or 10 µM.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Li, X., Xie, Y., Li, K., et al. Antioxidation and cytoprotection of acteoside and its derivatives: Comparison and mechanistic chemistry. Molecules 23(2), 498 (2018).

    2. Zhou, B.-N., Bahler, B.D., Hofmann, G.A., et al. Phenylethanoid glycosides from Digitalis purpurea and Penstemon linarioides with PKCα-inhibitory activity. J. Nat. Prod. 61(11), 1410-1412 (1998).

    3. Wu, A., Yang, Z., Huang, Y., et al. Natural phenylethanoid glycosides isolated from Callicarpa kwangtungensis suppressed lipopolysaccharide-mediated inflammatory response via activating Keap1/Nrf2/HO-1 pathway in RAW 264.7 macrophages cell. J. Ethnaopharmacol. 258, 112857 (2020).

    4. Koo, K.A., Sung, S.H., Park, J.H., et al. In vitro neuroprotective activities of phenylethanoid glycosides from Callicarpa dichotoma. Planta Med. 71(8), 778-780 (2005).