A phytoecdysteroid with diverse biological activities
Related Products
Isomer(s)
11741Muristerone A
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Turkesterone (hydrate)

Item No. 34665

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(2β,3β,5β,11α,22R)-2,3,11,14,20,22,25-heptahydroxy-cholest-7-en-6-one, hydrate
Molecular Formula
C27H44O8 • XH2O
Formula Weight
496.6
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: slightly solubleMethanol: slightly soluble
SMILES
O[C@]12C([C@@]([C@@H](C[C@@]1([C@]([C@@](C)(O)[C@H](O)CCC(C)(O)C)([H])CC2)C)O)([H])[C@@]3([C@@]4([H])C[C@H]([C@H](C3)O)O)C)=CC4=O.O
InChi Code
InChI=1S/C27H44O8.H2O/c1-23(2,33)8-7-21(32)26(5,34)20-6-9-27(35)15-11-16(28)14-10-17(29)18(30)12-24(14,3)22(15)19(31)13-25(20,27)4;/h11,14,17-22,29-35H,6-10,12-13H2,1-5H3;1H2/t14-,17+,18-,19+,20-,21+,22+,24-,25+,26+,27+;/m0./s1
InChi Key
KPDDBZPCPQHPNZ-ZSNHUFKWSA-N
Origin
Plant/Ajuga turkestanica
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $95

    Add

    5 mg

    $392

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Turkesterone is a phytoecdysteroid that has been found in A. turkestanica and has diverse biological activities.1 It binds to the ecdysteroid receptor (KD = 0.491 µM for the C. tentans receptor) and induces pupariation in G. mellonella, S. bullata, and D. vulpinus last instar larvae (ED50s = 10, 0.03, and 0.2 µg/larvae, respectively).2,3 Turkesterone scavenges DPPH (Item No. 14805) radicals in a cell-free assay (IC50 = 140.92 µg/ml) and is cytotoxic to HeLa cervical, HepG2 hepatic, and MCF-7 breast cancer cells (IC50s = 75.2, 63.01, and 105.2 µg/ml, respectively).1 It decreases serum glucose levels and increases serum insulin and C-peptide levels in a rat model of diabetes induced by alloxan (Item No. 9002196) when administered at a dose of 10 mg/kg.4 Turkesterone prevents immobilization stress-induced stomach ulcers in mice.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Mamadalieva, N.Z., El-Readi, M.Z., Ovidi, E., et al. Antiproliferative, antimicrobial and antioxidant activities of the chemical constituents of Ajuga turkestanica. Phytopharmacology 4(1), 1-18 (2013).

    2. Sláma, K., Abubakirov, N.K., Gorovits, M.B., et al. Hormonal activity of ecdysteroids from certain asiatic plants. Insect Biochem. Mol. Biol. 23(1), 181-185 (1993).

    3. Spindler-Barth, M., Quack, S., Rauch, P., et al. Biological effects of muristerone A and turkesterone on the epithelial cell line from Chironomus tentans (Diptera: Chironomidae) and correlation with binding affinity to the ecdysteroid receptor. Eur. J. Entomol. 94(2), 161-166 (1997).

    4. Kuchkarova, L.S., Rokhimova, S.O., and Syrov, V.N. Effect of turkesterone on the pancreas histology and function in diabetic rats. Int. J. Curr. Res. Rev. 12(21), 1-5 (2020).

    5. Shakhmurova, G.A., Syrov, V.N., and Khushbaktova, Z.A. Immunomodulating and antistress activity of ecdysterone and turkesterone under immobilization-induced stress conditions in mice. Pharm. Chem. J. 44(1), 7-9 (2010).