A flavonoid C-glycoside with diverse biological activities
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Swertisin

Item No. 34744

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-β-D-glucopyranosyl-5-hydroxy-2-(4-hydroxyphenyl)-7-methoxy-4H-1-benzopyran-4-one
CAS Number
6991-10-2
Synonyms
  • NSC 641547
Molecular Formula
C22H22O10
Formula Weight
446.4
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: soluble
λmax
216, 243, 276, 342 nm
SMILES
OC1=C2C(OC(C3=CC=C(C=C3)O)=CC2=O)=CC(OC)=C1[C@H]4[C@H](O)[C@H]([C@@H]([C@H](O4)CO)O)O
InChi Code
InChI=1S/C22H22O10/c1-30-13-7-14-16(11(25)6-12(31-14)9-2-4-10(24)5-3-9)19(27)17(13)22-21(29)20(28)18(26)15(8-23)32-22/h2-7,15,18,20-24,26-29H,8H2,1H3/t15-,18-,20+,21-,22+/m1/s1
InChi Key
ABRULANJVVJLFI-DGHBBABESA-N
Origin
Plant/Swertia bimaculata
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $83

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    5 mg

    $330

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    10 mg

    $578

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    25 mg

    $1,032

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Swertisin is a flavonoid C-glycoside that has been found in Swertia japonica and has diverse biological activities.1,2,3 It inhibits sodium-glucose cotransporter 2 (SGLT2) in HEK293 cells when used at a concentration of 7.5 µg/ml and is an adenosine A1 receptor antagonist (IC50 = 137 µM).1,2 Swertisin (0.2-5 µM) inhibits hepatitis B virus (HBV) replication in HepG2 2.2.15 cells.3 It decreases blood glucose levels in a mouse model of diabetes induced by streptozotocin (Item No. 13104), as well as prevents scopolamine-induced increases in escape latency in the Morris water maze in mice.1,2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bhardwaj, G., Vakani, M., Srivastava, A., et al. Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapy. Arch. Biochem. Biophys. 710, 108995 (2021).

    2. Lee, H.E., Jeon, S.J., Ryu, B., et al. Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property. Behav. Brain Res. 306, 137-145 (2016).

    3. Xu, H.-Y., Ren, J.-H., Su, Y., et al. Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim. J. Ethnopharmacol. 257, 112787 (2020).