A metabolite of leucine catabolism
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α-Ketoisocaproic Acid

Item No. 34749

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methyl-2-oxo-pentanoic acid
CAS Number
816-66-0
Synonyms
  • 2-Ketoisocaproate
  • α-Ketoisocaproate
  • 2-Ketoisocapronic Acid
  • KIC
  • 4-MOP
  • 2-Oxoisocaproic Acid
  • 4-methyl-2-Oxopentanoate
  • 4-methyl-2-Oxovaleric Acid
  • 4-methyl-2-Oxovalerate
Molecular Formula
C6H10O3
Formula Weight
130.1
Purity
≥95%
Formulation (Request formulation change)
A liquid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlEthanol: 30 mg/ml
λmax
241 nm
SMILES
O=C(C(CC(C)C)=O)O
InChi Code
InChI=1S/C6H10O3/c1-4(2)3-5(7)6(8)9/h4H,3H2,1-2H3,(H,8,9)
InChi Key
BKAJNAXTPSGJCU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 g

    $62

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    OBESITY RESEARCH SOLUTIONS
    Product Description

    α-Ketoisocaproic acid is a metabolite of L-leucine (Item No. 34342) catabolism.1 It increases the production of reactive species and decreases the activity of mitochondrial complex I, also known as NADH dehydrogenase, and complex II-III in the rat hippocampus when administered at an intracerebroventricular dose of 4 µmol.2 Urine levels of α-ketoisocaproic acid are reduced in db/db diabetic mice compared with heterozygous db/m non-diabetic mice.3 α-Ketoisocaproic acid accumulates in the tissues and body fluids of patients with maple syrup urine disease, an inborn error of metabolism characterized by branched-chain α-keto acid dehydrogenase (BCKAD) deficiency and leads to progressive ketoacidosis, failure to thrive, neurological dysfunction, and, potentially, death.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schiff, M., Ogier de Baulny, H., and Dionisi-Vici, C. Branched-chain organic acidurias/acidaemias. Inborn metabolic diseases: Diagnosis and treatment 277-294 (2016).

    2. Farias, H.R., Gabriel, J.R., Cecconi, M.L., et al. The metabolic effect of α-ketoisocaproic acid: In vivo and in vitro studies. Metab. Brain Dis. 36(1), 185-192 (2021).

    3. Kim, N.H., Hyeon, J.S., Kim, N.H., et al. Metabolic changes in urine and serum during progression of diabetic kidney disease in a mouse model. Arch. Biochem. Biophys. 646, 90-97 (2018).