A metabolite of leucine catabolism
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

α-Ketoisocaproic Acid (sodium salt)

Item No. 21052

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-methyl-2-oxo-pentanoic acid, monosodium salt
CAS Number
4502-00-5
Synonyms
  • 2-Ketoisocaproate
  • α-Ketoisocaproate
  • 2-Ketoisocaproic Acid
  • KIC
  • 4-MOP
  • 2-Oxoisocaproic Acid
  • 4-methyl-2-Oxopentanoate
  • 4-methyl-2-Oxovalerate
  • 4-methyl-2-Oxovaleric Acid
Molecular Formula
C6H9O3 • Na
Formula Weight
152.1
Purity
≥95%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Ethanol: 5 mg/mlPBS (pH 7.2): 10 mg/ml
SMILES
[O-]C(C(CC(C)C)=O)=O.[Na+]
InChi Code
InChI=1S/C6H10O3.Na/c1-4(2)3-5(7)6(8)9;/h4H,3H2,1-2H3,(H,8,9);/q;+1/p-1
InChi Key
IXFAZKRLPPMQEO-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 g

    $41

    Add

    5 g

    $178

    Add

    10 g

    $312

    Add

    25 g

    $611

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    α-Ketoisocaproic acid is a metabolite of L-leucine (Item No. 34342) catabolism.1 It increases the production of reactive species and decreases the activity of mitochondrial complex I, also known as NADH dehydrogenase, and complex II-III in the rat hippocampus when administered at an intracerebroventricular dose of 4 µmol.2 Urine levels of α-ketoisocaproic acid are reduced in db/db diabetic mice compared with heterozygous db/m non-diabetic mice.3 α-Ketoisocaproic acid accumulates in the tissues and body fluids of patients with maple syrup urine disease, an inborn error of metabolism characterized by branched-chain α-keto acid dehydrogenase (BCKAD) deficiency and leads to progressive ketoacidosis, failure to thrive, neurological dysfunction, and, potentially, death.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Schiff, M., Ogier de Baulny, H., and Dionisi-Vici, C. Branched-chain organic acidurias/acidaemias. Inborn metabolic diseases: Diagnosis and treatment 277-294 (2016).

    2. Farias, H.R., Gabriel, J.R., Cecconi, M.L., et al. The metabolic effect of α-ketoisocaproic acid: In vivo and in vitro studies. Metab. Brain Dis. 36(1), 185-192 (2021).

    3. Kim, N.H., Hyeon, J.S., Kim, N.H., et al. Metabolic changes in urine and serum during progression of diabetic kidney disease in a mouse model. Arch. Biochem. Biophys. 646, 90-97 (2018).