An internal standard for the quantification of L-methionine
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Unlabeled Version(s)
31721L-Methionine
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L-Methionine-d3

Item No. 34826

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
S-(methyl-d3)-L-homocysteine
CAS Number
13010-53-2
Molecular Formula
C5H8D3NO2S
Formula Weight
152.2
Purity
≥99% deuterated forms (d1-d3)
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: insolDMSO: insolEthanol: insolPBS (pH 7.2): 10 mg/ml
λmax
570 nm
SMILES
OC([C@@H](N)CCSC([2H])([2H])[2H])=O
InChi Code
InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1/i1D3
InChi Key
FFEARJCKVFRZRR-OSIBIXDNSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    L-Methionine-d3 is intended for use as an internal standard for the quantification of L-methionine by GC- or LC-MS. L-Methionine is an essential amino acid.1,2 It is catabolized by methionine adenosyltransferase 2A (MAT2A), yielding the universal methyl donor S-(5’-adenosyl-L-methionine (SAM; Item Nos. 16376 | 17595).2 L-methionine has roles in purine and pyrimidine synthesis, polyamine synthesis, and glutathione production, as well as in various metabolic diseases and aging. Dietary methionine restriction (MR) prevents accelerated aging in a mouse model of progeria and increases the lifespan of yeast, Drosophila, C. elegans, mice, and rats.1,2 MR also improves insulin sensitivity and reduces adiposity in mice, as well as inhibits the growth and proliferation of several cancer cell lines.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wanders, D., Hobson, K., and Ji, X. Methionine restriction and cancer biology. Nutrients 12(3), 684 (2020).

    2. Sanderson, S.M., Gao, X., Dai, Z., et al. Methionine metabolism in health and cancer: A nexus of diet and precision medicine. Nat. Rev. Cancer 19(11), 625-637 (2019).