An oxidized dimeric form of homocysteine
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Labeled Version(s)
43799DL-Homocystine-d8
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DL-Homocystine

Item No. 36223

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4,4′-dithiobis[2-amino-butanoic acid]
CAS Number
462-10-2
Synonyms
  • NSC 11337
  • NSC 43122
Molecular Formula
C8H16N2O4S2
Formula Weight
268.4
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
1N HCl: 10 mg/ml
SMILES
O=C(C(CCSSCCC(C(O)=O)N)N)O
InChi Code
InChI=1S/C8H16N2O4S2/c9-5(7(11)12)1-3-15-16-4-2-6(10)8(13)14/h5-6H,1-4,9-10H2,(H,11,12)(H,13,14)
InChi Key
ZTVZLYBCZNMWCF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    5 g

    $44

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    10 g

    $75

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    25 g

    $131

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    Product Description

    DL-Homocystine is an oxidized dimeric form of homocysteine (Item No. 30285). It inhibits CDNB-induced L-cystine (Item No. 31727) transport into isolated human erythrocytes by 75% when used at a concentration of 2.5 mM.1 DL-Homocystine increases the number of circulating endothelial cells and permeability of the pulmonary microcirculation and decreases the number of circulating platelets, as well as activates venostatic thrombosis induced by bowel loop ligation in a rat model of homocystinemia, an inborn error of metabolism characterized by a deficiency in cystathionine β-synthase (CBS) that is associated with thrombosis and atherosclerosis.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ohtsuka, Y., Kondo, T., and Kawakami, Y. Oxidative stresses induced the cystine transport activity in human erythrocytes. Biochem. Biophys. Res. Commun. 155(1), 160-166 (1988).

    2. Hladovec, J. Experimental homocystinemia, endothelial lesions and thrombosis. Blood Vessels 16(4), 202-205 (1979).