A BRD4 inhibitor
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Trotabresib

Item No. 36292

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-[2-(cyclopropylmethoxy)-5-(methylsulfonyl)phenyl]-2-methyl-1(2H)-isoquinolinone
CAS Number
1706738-98-8
Synonyms
  • BMS-986378
  • CC-90010
Molecular Formula
C21H21NO4S
Formula Weight
383.5
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 3 mg/mlDMSO: 3 mg/ml
SMILES
O=C1C2=C(C(C3=C(OCC4CC4)C=CC(S(=O)(C)=O)=C3)=CN1C)C=CC=C2
InChi Code
InChI=1S/C21H21NO4S/c1-22-12-19(16-5-3-4-6-17(16)21(22)23)18-11-15(27(2,24)25)9-10-20(18)26-13-14-7-8-14/h3-6,9-12,14H,7-8,13H2,1-2H3
InChi Key
UWZAJPITKGWMFJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $49

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    5 mg

    $182

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    10 mg

    $339

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    25 mg

    $723

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    Cayman Chemical
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    Product Description

    Trotabresib is an inhibitor of bromodomain-containing protein 4 (BRD4; IC50 = =0.5 µM).1 It inhibits the proliferation of Raji Burkitt’s lymphoma and HL-60 leukemia cells (IC50 = =0.5 µM for both).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Betancort, J.M., Stafford, J.A., Stansfield, R., et al. Bromodomain inhibitor. (2016).