A peptide antagonist of FPR2 and FPR3
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WRW4 (trifluoroacetate salt)

Item No. 36763

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-tryptophyl-L-arginyl-L-tryptophyl-L-tryptophyl-L-tryptophyl-L-tryptophanamide, trifluoroacetate salt
Synonyms
  • Trp-Arg-Trp-Trp-Trp-Trp-CONH2
  • Trp-Arg-Trp-Trp-Trp-Trp-NH2
  • WRWWWW-NH2
Molecular Formula
C61H65N15O6 • XCF3COOH
Formula Weight
1104.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMF: 12 mg/mlDMSO: 10 mg/mlEthanol: 20 mg/mlPBS (pH 7.2): 0.20 mg/ml
SMILES
O=C([C@H](CCCNC(N)=N)NC([C@@H](N)CC1=CNC2=CC=CC=C21)=O)N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@@H](CC5=CNC6=C5C=CC=C6)C(N[C@@H](CC7=CNC8=C7C=CC=C8)C(N[C@@H](CC9=CNC%10=C9C=CC=C%10)C(N)=O)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C61H65N15O6.C2HF3O2/c62-44(24-34-29-67-45-17-6-1-12-39(34)45)56(78)72-50(22-11-23-66-61(64)65)57(79)74-53(27-37-32-70-48-20-9-4-15-42(37)48)59(81)76-54(28-38-33-71-49-21-10-5-16-43(38)49)60(82)75-52(26-36-31-69-47-19-8-3-14-41(36)47)58(80)73-51(55(63)77)25-35-30-68-46-18-7-2-13-40(35)46;3-2(4,5)1(6)7/h1-10,12-21,29-33,44,50-54,67-71H,11,22-28,62H2,(H2,63,77)(H,72,78)(H,73,80)(H,74,79)(H,75,82)(H,76,81)(H4,64,65,66);(H,6,7)/t44-,50-,51-,52-,53-,54-;/m0./s1
InChi Key
KIPTTXFGLVJUMS-HNZNYIAHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    WRW4 is a peptide antagonist of formyl peptide receptor 2 (FPR2; IC50 = 0.23 µM) and FPR3, previously known as FPR-like 1 (FPRL1) and FPRL2, respectively.1,2 It inhibits increases in intracellular calcium and chemotaxis induced by the FPR1 and FPR2 agonist WKYMVm (Item No. 33589) in RBL-2H3 cells expressing FPR2 and by the FPR3 agonist F2L in isolated human monocytes when used at a concentration of 10 µM. WRW4 (10 µM) also prevents the production of superoxide induced by amyloid-β (1-42) (Aβ42; Item No. 20574) in isolated human neutrophils.1 In vivo, WRW4 (1 mg/kg) increases lung edema and bronchoalveolar lavage fluid (BALF) protein levels in the absence and presence of the antibiotic ceftriaxone (Item No. 18866) in a mouse model of acute lung injury induced by S. pneumoniae.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Bae, Y.-S., Lee, H.Y., Jo, E.J., et al. Identification of peptides that antagonize formyl peptide receptor-like 1-mediated signaling. J. Immunol. 173(1), 607-614 (2004).

    2. Shin, E.H., Lee, H.-Y., Kim, S.D., et al. Trp-Arg-Trp-Trp-Trp-Trp antagonizes formyl peptide receptor like 2-mediated signaling. Biochem. Biophys. Res. Commun. 341(4), 1317-1322 (2006).

    3. Siegel, E.R., Croze, R.H., Fang, X., et al. Inhibition of the lipoxin A4 and resolvin D1 receptor impairs host response to acute lung injury caused by pneumococcal pneumonia in mice. Am. J. Physiol. Lung Cell Mol. Physiol. 320(6), L1085-L1092 (2021).