A peptide fragment of GIP and a GIP receptor antagonist
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Glucose-dependent Insulinotropic Polypeptide (3-42) (human) (trifluoroacetate salt)

Item No. 36908

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-isoleucyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-L-alanyl-L-methionyl-L-α-aspartyl-L-lysyl-L-isoleucyl-L-histidyl-L-glutaminyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysylglycyl-L-lysyl-L-lysyl-L-asparaginyl-L-α-aspartyl-L-tryptophyl-L-lysyl-L-histidyl-L-asparaginyl-L-isoleucyl-L-threonyl-L-glutamine, trifluoroacetate salt
Synonyms
  • Gastric Inhibitory Peptide 1 (3-42)
  • GIP-1 (3-42)
Molecular Formula
C214H324N58O63S • XCF3COOH
Formula Weight
4749.3
Purity
≥90%
Formulation (Request formulation change)
A solid
Peptide Sequence
EGTFISDYSIAMDKIHQQDFVNWLLAQKGKKNDWKHNITQ-OH
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=C(O)CC[C@H](N[H])C(NCC(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@](C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](CO)C(N[C@@](C(N[C@H](C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@@](C(N[C@@H](CC2=CNC=N2)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC3=CNC4=C3C=CC=C4)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN[H])C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@@H](CC5=CNC6=C5C=CC=C6)C(N[C@@H](CCCCN[H])C(N[C@@H](CC7=CNC=N7)C(N[C@@H](CC(N)=O)C(N[C@@](C(N[C@]([C@H](O)C)([H])C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)=O)CC8=CC=CC=C8)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)C)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)CC9=CC=CC=C9)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C214H324N58O63S.C2HF3O2/c1-20-107(11)171(271-206(326)155(101-274)264-191(311)140(82-117-57-59-122(277)60-58-117)250-200(320)153(93-169(295)296)260-205(325)154(100-273)265-210(330)173(109(13)22-3)269-203(323)142(81-116-46-28-25-29-47-116)261-212(332)175(113(17)275)266-164(286)99-232-179(299)125(220)61-70-165(287)288)208(328)237-112(16)178(298)240-136(71-77-336-19)187(307)258-150(90-166(289)290)198(318)244-132(56-38-43-76-219)188(308)268-172(108(12)21-2)209(329)262-146(86-121-97-229-103-235-121)194(314)246-134(63-67-157(222)279)185(305)245-135(64-68-158(223)280)186(306)257-151(91-167(291)292)199(319)251-141(80-115-44-26-24-27-45-115)202(322)267-170(106(9)10)207(327)263-148(88-161(226)283)197(317)252-144(84-119-95-231-127-51-33-31-49-124(119)127)193(313)249-139(79-105(7)8)190(310)248-138(78-104(5)6)189(309)236-111(15)177(297)239-133(62-66-156(221)278)184(304)241-128(52-34-39-72-215)180(300)233-98-163(285)238-129(53-35-40-73-216)181(301)242-130(54-36-41-74-217)183(303)255-147(87-160(225)282)196(316)259-152(92-168(293)294)201(321)253-143(83-118-94-230-126-50-32-30-48-123(118)126)192(312)243-131(55-37-42-75-218)182(302)254-145(85-120-96-228-102-234-120)195(315)256-149(89-162(227)284)204(324)270-174(110(14)23-4)211(331)272-176(114(18)276)213(333)247-137(214(334)335)65-69-159(224)281;3-2(4,5)1(6)7/h24-33,44-51,57-60,94-97,102-114,125,128-155,170-176,230-231,273-277H,20-23,34-43,52-56,61-93,98-101,215-220H2,1-19H3,(H2,221,278)(H2,222,279)(H2,223,280)(H2,224,281)(H2,225,282)(H2,226,283)(H2,227,284)(H,228,234)(H,229,235)(H,232,299)(H,233,300)(H,236,309)(H,237,328)(H,238,285)(H,239,297)(H,240,298)(H,241,304)(H,242,301)(H,243,312)(H,244,318)(H,245,305)(H,246,314)(H,247,333)(H,248,310)(H,249,313)(H,250,320)(H,251,319)(H,252,317)(H,253,321)(H,254,302)(H,255,303)(H,256,315)(H,257,306)(H,258,307)(H,259,316)(H,260,325)(H,261,332)(H,262,329)(H,263,327)(H,264,311)(H,265,330)(H,266,286)(H,267,322)(H,268,308)(H,269,323)(H,270,324)(H,271,326)(H,272,331)(H,287,288)(H,289,290)(H,29
InChi Key
PCMPOMOCIGXLLS-UODVGNHTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    500 µg

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Gastric inhibitory peptide 1 (GIP-1) (3-42) is a peptide fragment of the incretin hormone GIP (Item No. 25004) and a GIP receptor antagonist.1 It is formed from GIP by serum dipeptidyl peptidase 4 (DDP-4). GIP-1 (3-42) (100 nM) reduces insulin secretion from BRIN-BD11 pancreatic cells. It increases plasma glucose levels and decreases plasma insulin levels in an ob/ob mouse model of diabetes when administered at a dose of 25 nmol/kg.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gault, V.A., Parker, J.C., Harriott, P., et al. Evidence that the major degradation product of glucose-dependent insulinotropic polypeptide, GIP(3-42), is a GIP receptor antagonist in vivo. J. Endocrinol. 175(2), 525-533 (2002).