For immunochemical detection of LDLR
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LDL Receptor Rabbit Monoclonal Antibody (Clone 004)

Item No. 37076

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • LDLR
  • Low Density Lipoprotein Receptor
Immunogen
Recombinant mouse LDLR
Clone Designation
004
Formulation (Request formulation change)
50 or 100 µl of protein A-affinity purified monoclonal antibody
Storage Buffer
0.2 μm filtered solution in PBS
Host
Rabbit
Isotype
IgG
Applications
ICC
Cross Reactivity
(+) LDLR
Species Reactivity
(+) Mouse
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    50 µl

    $145

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    100 µl

    $246

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    LDL receptor (LDLR) is a cell surface glycoprotein that scavenges LDL from the blood and regulates plasma LDL levels.1 It is composed of an N-terminal signal sequence, a ligand-binding domain, an EGF precursor homology domain, an O-linked glycosylation domain, a transmembrane region, and a C-terminal cytoplasmic tail. LDLR is primarily expressed in the liver but is also found in the adrenal cortex.2 It mediates the endocytosis of LDL by binding to apolipoprotein E (ApoE) or ApoB on the LDL surface, thereby supplying cholesterol to cells.1 Protein levels of LDLR are decreased in HepG2 cells expressing proprotein convertase subtilisin kexin 9 (PCSK9).3 Knockout of Ldlr increases plasma levels of cholesterol and triglycerides and induces the formation of atherosclerotic lesions in mice.4 Mutations in LDLR are associated with familial hypercholesterolemia.5 Cayman’s LDL Receptor Rabbit Monoclonal Antibody (Clone 004) can be used for immunocytochemistry (ICC) application.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Goldstein, J.L., Brown, M.S., Anderson, R.G.W., et al. Receptor-mediated endocytosis: Concepts emerging from the LDL receptor system. Annu. Rev. Cell Biol. 1, 1-39 (1985).

    2. Rudling, M.J., Reihnér, E., Einarsson, K., et al. Low density lipoprotein receptor-binding activity in human tissues: Quantitative importance of hepatic receptors and evidence for regulation of their expression in vivo. Proc. Natl. Acad. Sci. USA 87(9), 3469-3473 (1990).

    3. Benjannet, S., Rhainds, D., Essalmani, R., et al. NARC-1/PCSK9 and its natural mutants. Zymogen cleavage and effects on the low density lipoprotein (LDL) receptor and LDL cholesterol. The Journal of Biological Chemisty 279(47), 48865-48875 (2004).

    4. Praticò, D., Tillmann, C., Zhang, Z.B., et al. Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. Proc. Natl. Acad. Sci. USA 98(6), 3358-3363 (2001).

    5. Austin, M.A., Hutter, C.M., Zimmern, R.L., et al. Genetic causes of monogenic heterozgous familial hypercholesterolemia: A HuGE prevalence review. Am. J. Epidemiol. 160(5), 407-420 (2004).