A perfluoroalkyl substance
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Perfluorotridecanoic Acid

Item No. 37256

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2,2,3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,12,12,13,13,13-pentacosafluoro-tridecanoic acid
CAS Number
72629-94-8
Synonyms
  • PFTrDA
Molecular Formula
C13HF25O2
Formula Weight
664.1
Purity
≥80%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Ethanol: Slightly soluble
SMILES
O=C(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(C(F)(F)F)F)F)F)F)F)F)F)F)F)F)F)O
InChi Code
InChI=1S/C13HF25O2/c14-2(15,1(39)40)3(16,17)4(18,19)5(20,21)6(22,23)7(24,25)8(26,27)9(28,29)10(30,31)11(32,33)12(34,35)13(36,37)38/h(H,39,40)
InChi Key
LVDGGZAZAYHXEY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    Perfluorotridecanoic acid (PFTrDA) is a perfluoroalkyl substance (PFAS). Embryo-larval exposure of PFTrDA induces yolk sac edema and increases mRNA expression of thyroid hormone synthesis genes, including tshβ, in zebrafish when used at concentrations of 0.1 and 0.3 mg/L, respectively.1 PFTrDA (10 mg/kg) decreases serum testosterone and luteinizing hormone levels, testis palmitic acid (Item No. 10006627), linoleic acid (Item Nos. 90150 | 90150.1 | 21909), and oleic acid (Item Nos. 90260 | 24659) levels, and the number of Leydig cells in rats in late puberty.2 Maternal plasma levels of PFTrDA during gestation are positively associated with the development of eczema in female, but not male, infants, and liver levels of PFTrDA are higher in cancerous human livers compared with non-cancerous human livers.3,4 It has been found in marine mammals.5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kim, J., Lee, G., Lee, Y.-M., et al. Thyroid disrupting effects of perfluoroundecanoic acid and perfluorotridecanoic acid in zebrafish (Danio rerio) and rat pituitary (GH3) cell line. Chemosphere 262, 128012 (2021).

    2. Zou, C., Yan, H., Wen, Z., et al. Perfluorotridecanoic acid inhibits Leydig cell maturation in male rats in late puberty via changing testicular lipid component. Chem. Res. Toxicol. 34(6), 1542-1555 (2021).

    3. Okada, E., Sasaki, S., Kashino, I., et al. Prenatal exposure to perfluoroalkyl acids and allergic diseases in early childhood. Environ. Int. 65, 127-134 (2014).

    4. Liu, Y., Lin, N., Dai, C., et al. Occurrence and distribution of per- and polyfluoroalkyl substances (PFASs) in human livers with liver cancer. Environ. Res. 202, 111775 (2021).

    5. Rotander, A., Kärrman, A., van Bavel, B., et al. Increasing levels of long-chain perfluorocarboxylic acids (PFCAs) in Arctic and North Atlantic marine mammals, 1984-2009. Chemosphere 86(3), 278-285 (2012).