A dioxin-like polychlorinated dibenzofuran
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1,2,3,4,7,8-Hexachlorodibenzofuran

Item No. 38619

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
CAS Number
70648-26-9
Synonyms
  • 1,2,3,4,7,8-HxCDF
  • PCDF 118
Molecular Formula
C12H2Cl6O
Formula Weight
374.9
Purity
≥90%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
Chloroform: Slightly soluble upon heating
SMILES
ClC1=C(Cl)C=C2C3=C(C(Cl)=C(C(Cl)=C3Cl)Cl)OC2=C1
InChi Code
InChI=1S/C12H2Cl6O/c13-4-1-3-6(2-5(4)14)19-12-7(3)8(15)9(16)10(17)11(12)18/h1-2H
InChi Key
LVYBAQIVPKCOEE-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $392

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    Cayman Chemical
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    Product Description

    1,2,3,4,7,8-Hexachlorodibenzofuran is a dioxin-like polychlorinated dibenzofuran (PCDF).1 It induces the expression of the genes encoding the cytochrome P450 (CYP) isoforms CYP1A1 and CYP1B1, as well as the aryl hydrocarbon receptor repressor (AhRR) in primary human peripheral blood lymphocytes and increases ethoxyresorufin-O-deethylase (EROD) activity, a marker of CYP1A1 activity, in isolated human peripheral blood lymphocytes in a concentration-dependent manner. 1,2,3,4,7,8-Hexachlorodibenzofuran (300, 600, and 1,000 µg/kg) increases the percentage of mouse fetuses with cleft palates or hydronephrosis in pregnant dams.2 It has been found in human breastmilk, freshwater fish, and in the air near municipal waste incinerators.3,4,5

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. van Ede, K.I., Gaisch, K.P.J., van den Berg, M., et al. Differential relative effect potencies of some dioxin-like compounds in human peripheral blood lymphocytes and murine splenic cells. Toxicol. Lett. 226(1), 43-52 (2014).

    2. Birnbaum, L.S., Harris, M.W., Barnhart, E.R., et al. Teratogenicity of three polychlorinated dibenzofurans in C57BL/6N mice. Toxicol. Appl. Pharmacol. 90(2), 206-216 (1987).

    3. Tawara, K., Nishijo, M., Honda, R., et al. Effects of maternal dioxin exposure on newborn size at birth among Japanese mother-infant pairs. Environ. Health Prev. Med. 14(2), 88-95 (2009).

    4. Takekuma, M., Saito, K., Ogawa, M., et al. Levels of PCDDs, PCDFs and Co-PCBs in human milk in Saitama, Japan, and epidemiological research. Chemosphere 54(1), 127-135 (2004).

    5. Hu, S.-W., ChangChien, G.-P., and Chan, C.-C. PCDD/Fs levels in indoor environments and blood of workers of three municipal waste incinerators in Taiwan. Chemosphere 55(4), 611-620 (2004).