A P2Y11 receptor agonist
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Adenosine-5'-O-(3-thiotriphosphate) (sodium salt)

Item No. 38635

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
adenosine 5′-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid, tetrasodium salt
CAS Number
88453-52-5
Synonyms
  • Adenosine 5'-(γ-thio)-triphosphate
  • ATPγS
Molecular Formula
C10H12N5O12P3S • 4Na
Formula Weight
611.2
Purity
≥95%
Formulation (Request formulation change)
A 10 mM solution in water
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O[C@@H]1[C@@H](COP(OP(OP([O-])([S-])=O)([O-])=O)([O-])=O)O[C@@H](N2C3=NC=NC(N)=C3N=C2)[C@@H]1O.[Na+].[Na+].[Na+].[Na+]
InChi Code
InChI=1S/C10H16N5O12P3S.4Na/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(25-10)1-24-28(18,19)26-29(20,21)27-30(22,23)31;;;;/h2-4,6-7,10,16-17H,1H2,(H,18,19)(H,20,21)(H2,11,12,13)(H2,22,23,31);;;;/q;4*+1/p-4/t4-,6-,7-,10-;;;;/m1..../s1
InChi Key
PBVFEDMHGRBQSV-KWIZKVQNSA-J
Shipping & Storage Information
Storage
-80°C
Shipping
Dry ice in continental US; may vary elsewhere
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    2.6 mg

    $175

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    Product Description

    Adenosine-5'-O-(3-thiotriphosphate) (ATPγS) is an agonist of the purinergic P2Y11 receptor.1 It induces inositol phosphate accumulation in CHO-K1 cells expressing the human or canine P2Y11 receptor (EC50s = 1.2 and 19.3 µM, respectively). ATPγS (10 µM) inhibits Junin virus-induced increases in mRNA encoding bone morphogenetic protein 6 (BMP6) and reduces particle forming units (PFUs) in Junin virus-infected primary rat osteoblasts.2 It induces insulin secretion by MIN6 pancreatic β-cells when used at a concentration of 25 µM.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Qi, A.D., Zambon, A.C., Insel, P.A., et al. An arginine/glutamine difference at the juxtaposition of transmembrane domain 6 and the third extracellular loop contributes to the markedly different nucleotide selectivities of human and canine P2Y11 receptors. Mol. Pharmacol. 60(6), 1375-1382 (2001).

    2. Ayala-Peña, V.B., Armiento, M.N., Fernández Bell Fano, P.M., et al. Infection of rat osteoblasts with junin virus promotes the expression of bone morphogenetic protein 6, an osteogenic differentiation inducer. Intervirology 62(1), 1-8 (2019).

    3. Hauke, S., Rada, J., Tihanyi, G., et al. ATP is an essential autocrine factor for pancreatic β-cell signaling and insulin secretion. Physiol. Rep. 10(1), e15159 (2022).