An intermediate in the glucuronic acid pathway
Related Products
Isomer(s)
14656L-Ascorbic Acid
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D-Glucurone

Item No. 40301

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
D-glucuronic acid, γ-lactone
CAS Number
32449-92-6
Synonyms
  • D-Glucuronolactone
  • NSC 656
Molecular Formula
C6H8O6
Formula Weight
176.1
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly solubleWater: Soluble
SMILES
O=C[C@@H]([C@]1([H])[C@@H]([C@@H](C(O1)=O)O)O)O
InChi Code
InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h1-5,8-10H/t2-,3+,4-,5+/m0/s1
InChi Key
UYUXSRADSPPKRZ-SKNVOMKLSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    25 g

    $28

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    50 g

    $42

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    100 g

    $72

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    250 g

    $152

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    Product Description

    D-Glucurone is an intermediate in the glucuronic acid pathway.1,2 It is formed from D-glucuronic acid (Item No. 31531) spontaneously or by uronolactonase and is converted to L-ascorbic acid (Item No. 14656) via a L-gulonolactone intermediate. D-Glucurone (1 µg/ml) prevents increases in alanine transaminase (ALT) and aspartate aminotransferase (AST) activities, as well as malondialdehyde (MDA) levels, and protects against decreases in cell viability, superoxide dismutase (SOD) activity, and glutathione (GSH) levels, induced by the mycotoxin ochratoxin A (Item No. 11439) in primary chicken hepatocytes.3 In vivo, D-glucurone (1 mg/ml in the tank water) prevents decreases in neuronal excitability and reverses deficits in a visual avoidance assay in a Xenopus model of neurotoxicity induced by the solvent p-xylene.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Horio, F., Kimura, M., and Yoshida, A. Effect of several xenobiotics on the activities of enzymes affecting ascorbic acid synthesis in rats. J. Nutr. Sci. Vitaminol. (Tokyo) 29(3), 233-247 (1983).

    2. Sauer, M., Branduardi, P., Valli, M., et al. Production of L-ascorbic acid by metabolically engineered Saccharomyces cerevisiae and Zygosaccharomyces bailii. Appl. Environ. Microbiol. 70(10), 6086-6091 (2004).

    3. Yu, Z., Wu, F., Tian, J., et al. Protective effects of compound ammonium glycyrrhizin, L‑arginine, silymarin and glucurolactone against liver damage induced by ochratoxin A in primary chicken hepatocytes. Mol. Med. Rep. 18(3), 2551-2560 (2018).

    4. Liao, Y., Luo, Y., Ding, N., et al. D-Glucuronolactone attenuates para-xylene-induced defects in neuronal development and plasticity in Xenopus tectum in vivo. Toxicology 430, 152341 (2020).