A derivative of uridine
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2'-Fluoro-2'-deoxyuridine

Item No. 40302

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2′-deoxy-2′-fluoro-uridine
CAS Number
784-71-4
Synonyms
  • 2'-FdU
Molecular Formula
C9H11FN2O5
Formula Weight
246.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Soluble: ≥10 mg/ml
SMILES
F[C@H]1[C@H](N2C(NC(C=C2)=O)=O)O[C@@H]([C@H]1O)CO
InChi Code
InChI=1S/C9H11FN2O5/c10-6-7(15)4(3-13)17-8(6)12-2-1-5(14)11-9(12)16/h1-2,4,6-8,13,15H,3H2,(H,11,14,16)/t4-,6-,7-,8-/m1/s1
InChi Key
UIYWFOZZIZEEKJ-XVFCMESISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

    $28

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    5 mg

    $97

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    10 mg

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    25 mg

    $310

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    Cayman Chemical
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    Product Description

    2'-Fluoro-2'-deoxyuridine (2'-FdU) is a derivative of the pyrimidine nucleoside uridine (Item No. 20300).1 Hepatitis C polyU/UC RNA strands containing 2'-FdU, unlike unmodified polyU/UC strands, bind to retinoic acid-inducible gene I (RIG-I) but do not activate RIG-I signaling in a reporter assay using Huh7 cells. 2'-FdU also has been used as a starting material in the synthesis of respiratory syncytial virus (RSV) polymerase inhibitors.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Durbin, A.F., Wang, C., Marcotrigiano, J., et al. RNAs containing modified nucleotides fail to trigger RIG-I conformational changes for innate immune signaling. mBio 7(5), e00833 (2016).

    2. Wang, G., Deval, J., Hong, J., et al. Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection. J. Med. Chem. 58(4), 1862-1878 (2015).