An active metabolite of 5-fluorouracil
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Floxuridine

Item No. 14154

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2'-deoxy-5-fluoro-uridine
CAS Number
50-91-9
Synonyms
  • 5-FDU
  • FdUrd
  • 5-Fluorodeoxyuridine
  • 5-FUDR
  • NSC 26740
  • NSC 27640
Molecular Formula
C9H11FN2O5
Formula Weight
246.2
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 16 mg/mlDMSO: 10 mg/mlPBS (pH 7.2): 5 mg/ml
λmax
269 nm
SMILES
OC[C@@H]1[C@@H](O)C[C@H](N2C=C(F)C(NC2=O)=O)O1
InChi Code
InChI=1S/C9H11FN2O5/c10-4-2-12(9(16)11-8(4)15)7-1-5(14)6(3-13)17-7/h2,5-7,13-14H,1,3H2,(H,11,15,16)/t5-,6+,7+/m0/s1
InChi Key
ODKNJVUHOIMIIZ-RRKCRQDMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    50 mg

    $57

    Add

    100 mg

    $91

    Add

    500 mg

    $363

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    Floxuridine is an active metabolite of the fluorodeoxyuridylate (FdUMP) prodrug 5-fluorouracil (5-FU; Item No. 14416).1 It is formed from 5-FU by thymidine phosphorylase, which is then phosphorylated by thymidine kinase to form FdUMP. Floxuridine (1 µM) induces DNA double-strand breaks in thymidylate synthase-deficient FM3A murine breast cancer cells, as well as increases dATP levels and decreases dTTP and dGTP levels in FM3A F28-7 murine breast cancer cells expressing wild-type thymidylate synthase.2 It inhibits the proliferation of L1210 leukemia and HeLa cancer cells (IC50s = 1.1 and 9.4 nM, respectively).1 Floxuridine (200 mg/kg, i.p.) reduces tumor growth by 86.3% in a S180 murine sarcoma model.3 Formulations containing floxuridine have previously been used in the treatment of metastatic gastrointestinal adenocarcinoma.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tzioumaki, N., Manta, S., Tsoukala, E., et al. Synthesis and biological evaluation of unsaturated keto and exomethylene D-arabinopyranonucleoside analogs: Novel 5-fluorouracil analogs that target thymidylate synthase. Eur. J. Med. Chem. 46(4), 993-1005 (2011).

    2. Yoshioka, A., Tanaka, S., Hiraoka, O., et al. Deoxyribonucleoside triphosphate imbalance. 5-Fluorodeoxyuridine-induced DNA double strand breaks in mouse FM3A cells and the mechanism of cell death. The Journal of Biological Chemisty 262(17), 8235-8241 (1987).

    3. Bollag, W., and Hartmann, H.R. Tumor inhibitory effects of a new fluorouracil derivative: 5'-Deoxy-5-fluorouridine. Eur. J. Cancer 16(4), 427-432 (1980).