A MEK1 inhibitor
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Nedometinib

Item No. 40465

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)-1-methyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide
CAS Number
2252314-46-6
Synonyms
  • NFX-179
Molecular Formula
C17H16FIN4O3
Formula Weight
470.2
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: SolubleMethanol: Soluble
SMILES
O=C(C(C1=CC=CN=C1N2C)=C2NC(C=CC(I)=C3)=C3F)NOCCO
InChi Code
InChI=1S/C17H16FIN4O3/c1-23-15-11(3-2-6-20-15)14(17(25)22-26-8-7-24)16(23)21-13-5-4-10(19)9-12(13)18/h2-6,9,21,24H,7-8H2,1H3,(H,22,25)
InChi Key
SENAOZROGSYRTD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $109

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    Product Description

    Nedometinib is a MEK1 inhibitor (IC50 = 135 nM).1 It is selective for MEK1 over a panel of 44 receptors, ion channels, and enzymes at 10 µM, as well as a panel of an additional 150 kinases. Nedometinib (0.1-10 µM) decreases phosphorylation of ERK in malignant peripheral nerve sheath tumor cells. Topical application of nedometinib (0.1-2.3%) reduces the total number of tumors in a mouse model of cutaneous squamous cell carcinoma induced by UV radiation.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Sarin, K.Y., J., K., B., S., et al. Development of a MEK inhibitor, NFX-179, as a chemoprevention agent for squamous cell carcinoma. Sci. Transl. Med. 15(717), (2023).