A Certified Reference Material
Features
  • This product is qualified as a Certified Reference Material (CRM) that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This CRM has been characterized by metrologically valid procedures and may be used as a quantitative analytical reference standard
  • Certificate of analysis provides the certified property values and the associated uncertainties, including a statement of metrological traceability for the certified values
  • Possession of a DEA Controlled Substance registration is not necessary nor is a DEA 222 form required to purchase this product
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
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Noroxymorphone (hydrochloride) (CRM)

A 1 mg/ml solution in 80:20 methanol/DMSO

Item No. 41701

Exempt Product (US)
Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • EN 3169
  • (-)-Noroxymorphone
Technical Information
Formal Name
4,5α-epoxy-3,14-dihydroxy-morphinan-6-one, monohydrochloride
CAS Number
52446-24-9
Molecular Formula
C16H17NO4 • HCl
Formula Weight
323.8
Formulation
A 1 mg/ml solution in 80:20 methanol/DMSO
SMILES
O[C@]12[C@]3(CCN[C@@H]2C4)[C@](OC5=C3C4=CC=C5O)([H])C(CC1)=O.Cl
InChi Code
InChI=1S/C16H17NO4.ClH/c18-9-2-1-8-7-11-16(20)4-3-10(19)14-15(16,5-6-17-11)12(8)13(9)21-14;/h1-2,11,14,17-18,20H,3-7H2;1H/t11-,14+,15+,16-;/m1./s1
InChi Key
QMFVIJMHPXUVOL-RCGDHTHDSA-N
Regulatory Information
DEA Exempt Notification
This product is a DEA exempt preparation of a scheduled compound - does not require DEA Controlled Substance registration or DEA 222 form. For alternate sizes please contact sales.
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

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    Product Description

    Noroxymorphone (hydrochloride) (CRM) (Item No. 41701) is a certified reference material categorized as an opioid.1 Noroxymorphone is an active metabolite of oxycodone (Item Nos. ISO60148 | 15465), noroxycodone (Item Nos. 35521 | 27217), and oxymorphone (Item Nos. ISO60171 | 15911 | 29435).2,3,4 It is a precursor in the synthesis of naltrexone (Item Nos. ISO60192 | 15520) and naloxone (Item Nos. ISO60191 | 15594).5 Noroxymorphone is regulated as a Schedule II compound in the United States. Noroxymorphone (hydrochloride) (CRM) (Item No. 41701) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Thompson, C.M., Wojno, H., Greiner, E., et al. Activation of G-proteins by morphine and codeine congeners: Insights to the relevance of O- and N-demethylated metabolites at μ- and δ-opioid receptors. J. Pharmacol. Exp. Ther. 308(2), 547-554 (2004).

    2. Kokki, M., Heikkinen, M., Valitalo, P., et al. Maturation of oxycodone pharmacokinetics in neonates and infants: Oxycodone and its metabolites in plasma and urine. Br. J. Clin. Pharmacol. 83(4), 791-800 (2016).

    3. Korjamo, T., Tolonen, A., Ranta, V.-P., et al. Metabolism of oxycodone in human hepatocytes from different age groups and prediction of hepatic plasma clearance. Front. Pharmacol. 2:87, (2012).

    4. Lalovic, B., Phillips, B., Risler, L.L., et al. Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug Metab. Dispos. 32(4), 447-454 (2004).

    5. Gutmann, B., Weigl, U., Cox, D.P., et al. Batch- and continuous-flow aerobic oxidation of 14-hydroxy opioids to 1,3-oxazolidines-A concise synthesis of noroxymorphone. Chemistry 22(30), 10393-10398 (2016).