A PEGylated form of C16 ceramide
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C16 Ceramide-mPEG(2000)

Item No. 41955

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[4-[[(2S,3R,4E)-3-hydroxy-2-[(1-oxohexadecyl)amino]-4-octadecen-1-yl]oxy]-1,4-dioxobutyl]-ω-methoxy-poly(oxy-1,2-ethanediyl)
CAS Number
212116-78-4
Synonyms
  • Cer(d18:1/16:0) MPEG(2000)
  • MPEG(2000) Ceramide (d18:1/16:0)
  • N-Hexadecanoyl-D-erythro-Sphingosine mPEG(2000)
  • N-Palmitoyl-D-erythro-Sphingosine mPEG(2000)
  • Palmitoyl Ceramide Methoxy Polyethylene Glycol-2000
Molecular Formula
(C2H4O)nC39H73NO6
Purity
≥90%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Methanol: Sparingly soluble: 1-10 mg/ml
SMILES
CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC(CCCCCCCCCCCCCCC)=O)COC(CCC(OCCOC)=O)=O
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $53

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    5 mg

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    10 mg

    $423

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    Cayman Chemical
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    Product Description

    C16 Ceramide-mPEG(2000) is a PEGylated form of C16 ceramide (Item No. 10681) that has been used in the generation of microspheres, lipid nanoparticles (LNPs), and liposomes for the delivery of small molecules, mRNA, and plasmid DNA in vitro and in vivo.1,2,3 Liposomes containing C16 ceramide-mPEG(2000) and a stearylated derivative of the endosomal escape inducer INF7 have been used to transfect plasmid DNA into MFLM-4 cells.1 Microspheres containing C16 ceramide-mPEG(2000) and encapsulating oxaliplatin (Item No. 13106) increase survival and decrease the number of small intestine, colon, and cecum polyps in an Apc+/Min spontaneous colorectal adenoma mouse model.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kusumoto, K., Akita, H., El-Sayed, A., et al. Effect of the anchor in polyethylene glycol-lipids on the transfection activity of PEGylated cationic liposomes encapsulating DNA. Biol. Pharm. Bull. 35(4), 445-448 (2012).

    2. Urbanska, A.M., Karagiannis, E.D., Guajardo, G., et al. Therapeutic effect of orally administered microencapsulated oxaliplatin for colorectal cancer. Biomaterials 33(18), 4752-4761 (2012).

    3. Lee, Y., Jeong, M., Lee, G., et al. Development of lipid nanoparticle formulation for the repeated administration of mRNA therapeutics. Biomater. Res. 28, 0017 (2024).