A free radical scavenger and necrosis and ferroptosis inhibitor
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NecroX-7

Item No. 42135

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-(tetrahydro-2H-pyran-4-yl)-1H-indol-7-amine
CAS Number
1120332-55-9
Synonyms
  • LC28-0126
  • Necrosis Inhibitor 7
Molecular Formula
C24H29N3O3S
Formula Weight
439.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile: Slightly soluble: 0.1-1 mg/mlDMSO: Sparingly soluble: 1-10 mg/ml
SMILES
O=S1(CCN(CC1)CC2=CC3=C(C(NC4CCOCC4)=C2)NC(C5=CC=CC=C5)=C3)=O
InChi Code
InChI=1S/C24H29N3O3S/c28-31(29)12-8-27(9-13-31)17-18-14-20-16-22(19-4-2-1-3-5-19)26-24(20)23(15-18)25-21-6-10-30-11-7-21/h1-5,14-16,21,25-26H,6-13,17H2
InChi Key
UZRCNCPUOFYHRB-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $138

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    10 mg

    $248

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    25 mg

    $585

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    50 mg

    $895

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    Product Description

    NecroX-7 is a free radical scavenger and necrosis and ferroptosis inhibitor.1,2,3 It scavenges DPPH (Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays (EC50s = 2.6 and 11.96 µM, respectively).1 NecroX-7 inhibits necrosis induced by tert-butyl hydroperoxide (tBHP) in H9c2 cardiomyocytes and ferroptosis induced by erastin (Item No. 17754) in HT-1080 cells (IC50s = 57 and 6 nM, respectively).2,3 It reduces the activity of NADPH oxidase (NOX) by 53.3% in H9c2 lysates when used at a concentration of 25 µM.2 NecroX-7 (25 µM) prevents acetaminophen-induced decreases in cell viability and increases in reactive oxygen species (ROS) and reactive nitrogen species (RNS) production in primary mouse hepatocytes.1 In vivo, NecroX-7 (100 mg/kg) reduces doxorubicin-induced cardiomyopathy in rats.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, J.-H., Seo, K.-S., Tadi, S., et al. An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice. Antioxid. Redox Signal. 18(14), 1712-1722 (2013).

    2. Park, J., Park, E., Ahn, B.-H., et al. NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats. Toxicol. Appl. Pharmacol. 263(1), 1-6 (2012).

    3. Lu, Y., Shen, Z., Xu, Y., et al. Discovery of new phenyltetrazolium derivatives as ferroptosis inhibitors for treating ischemic stroke: An example development from free radical scavengers. J. Med. Chem. 67(14), 11712-11731 (2024).