A PAK2 inhibitor and an immunosuppressant
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

PQA-18

Item No. 42351

Product Insert (PDF)
Technical Information
Formal Name
4,8-bis[(3-methyl-2-buten-1-yl)oxy]-2-quinolinecarboxylic acid, 3-methyl-2-buten-1-yl ester
CAS Number
1604678-82-1
Synonyms
  • Prenylated Quinolinecarboxylic Acid Compound-18
Molecular Formula
C25H31NO4
Formula Weight
409.5
Purity
≥98%
Formulation (Request formulation change)
A solid
SMILES
C/C(C)=C/COC1=C(C=CC=C2OC/C=C(C)\C)C2=NC(C(OC/C=C(C)/C)=O)=C1
InChi Code
InChI=1S/C25H31NO4/c1-17(2)10-13-28-22-9-7-8-20-23(29-14-11-18(3)4)16-21(26-24(20)22)25(27)30-15-12-19(5)6/h7-12,16H,13-15H2,1-6H3
InChi Key
APPXFGJVXDYNBO-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    5 mg

    $468

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    PQA-18 is an inhibitor of p21-activated kinase 2 (PAK2; IC50 = 10 nM), an immunosuppressant, and a derivative of Ppc-1 (Item No. 42352).1 It inhibits the production of IL-2 induced by concanavalin A (Item No. 14951) in Jurkat T cells (IC50 = 400 nM). Topical application of PQA-18 (0.1%) decreases disease severity, serum IgE levels, and skin thickness in the NC/Nga mouse model of atopic dermatitis. It also reduces cutaneous nerve fiber density in NC/Nga mice when applied topically at 0.05%.2 PQA-18 (4 mg/kg) increases graft survival rate in a rat model of small intestine transplant.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ogura, M., Kikuchi, H., Suzuki, T., et al. Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2. Biochem Pharmacol. 105, 55-65 (2016).

    2. Ogura, M., Endo, K., Suzuki, T., et al. Prenylated quinolinecarboxylic acid compound-18 prevents sensory nerve fiber outgrowth through inhibition of the interleukin-31 pathway. PLoS One 16(2), e0246630 (2021).

    3. Kodama, T., Maeda, A., Lo, P.-C., et al. The effect of a novel immunosuppressive drug, a PAK-2 inhibitor, on macrophage differentiation/polarization in a rat small intestinal transplantation model. Transpl. Immunol. 57, 101246 (2019).