A dual inhibitor of Cdk6 and BRD4
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BC13

Item No. 42704

Product Insert (PDF)
Technical Information
Formal Name
8-cyclopentyl-2-[2-[4-(3,4-dihydro-5,7-dimethoxy-4-oxo-2-quinazolinyl)benzoyl]-2,7-diazaspiro[3.5]non-7-yl]-5-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one
CAS Number
3036645-03-8
Molecular Formula
C37H39N7O5
Formula Weight
661.8
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
Chloroform: Sparingly Soluble: 1-10 mg/ml
SMILES
CC1=CC(N(C2=C1C=NC(N3CCC4(CN(C(C5=CC=C(C6=NC(C7=C(N6)C=C(OC)C=C7OC)=O)C=C5)=O)C4)CC3)=N2)C8CCCC8)=O
InChi Code
InChI=1S/C37H39N7O5/c1-22-16-30(45)44(25-6-4-5-7-25)33-27(22)19-38-36(41-33)42-14-12-37(13-15-42)20-43(21-37)35(47)24-10-8-23(9-11-24)32-39-28-17-26(48-2)18-29(49-3)31(28)34(46)40-32/h8-11,16-19,25H,4-7,12-15,20-21H2,1-3H3,(H,39,40,46)
InChi Key
GCDVHXYXNPHYTC-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

    $102

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    5 mg

    $456

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    10 mg

    $810

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    Product Description

    BC13 is a dual inhibitor of cyclin-dependent kinase 6 (Cdk6) and bromodomain-containing protein 4 (BRD4; IC50s = 36.03, 234.12, and 137.42 nM for Cdk6 and BRD4 bromodomain 1 (BD1) and BD2), respectively).1 It is selective for Cdk6 over Cdk1-Cdk5 at 500 nM and for BD1 and BD2 in BRD4 over those in BRD2 and BRD3 (IC50s = >1,000, >1,000, 863.41, and 967.5 nM, respectively). It inhibits the proliferation of MDA-MB-231 and BT-549 triple-negative breast cancer (TNBC) cells (IC50s = 2,250 and 980 nM, respectively) but not non-cancerous MCF-10A cells (IC50 = >16.1 µM). BC13 (2 µM) in combination with the ferroptosis inducer RSL3 (Item No. 19288) synergistically reduces colony formation of MDA-MB-231 cells. It also reduces tumor growth in an MDA-MB-231 mouse xenograft model when administered at a dose of 25 mg/kg every other day.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Zhang, Y., Zheng, L., Ma, L., et al. Discovery of dual CDK6/BRD4 inhibitor inducing apoptosis and increasing the sensitivity of ferroptosis in triple-negative breast cancer. J. Med. Chem. 67(23), 21186-21207 (2024).