A STAT3 inhibitor
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W1131

Item No. 42902

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
5-nitro-N-[4-[7-(1,2,3,6-tetrahydro-4-pyridinyl)imidazo[1,2-a]pyridin-3-yl]phenyl]-2-furancarboxamide
CAS Number
2740522-79-4
Molecular Formula
C23H19N5O4
Formula Weight
429.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(C3=CN=C4C=C(C=CN43)C5=CCNCC5)C=C2
InChi Code
InChI=1S/C23H19N5O4/c29-23(20-5-6-22(32-20)28(30)31)26-18-3-1-16(2-4-18)19-14-25-21-13-17(9-12-27(19)21)15-7-10-24-11-8-15/h1-7,9,12-14,24H,8,10-11H2,(H,26,29)
InChi Key
CMVDOFFRPTYZID-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

    1 mg

    $76

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    5 mg

    $343

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    10 mg

    $532

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    25 mg

    $1,044

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    Cayman Chemical
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    Product Description

    W1131 is a STAT3 inhibitor.1 It selectively inhibits the phosphorylation of STAT3 over STAT1, STAT5, JAK2, and Akt in AGS gastric adenocarcinoma cells at 3 µM. W1131 binds to STAT3 in a cell-free assay (Kd = 7.55 µM) and increases the thermal stability of STAT3 in a cellular thermal shift assay (CETSA) using AGS cells when used at a concentration of 1 µM. It also inhibits STAT3 dimerization, nuclear accumulation, and transcriptional activation in cell-based assays. W1131 (3 µM) induces cell death in AGS cells, which can be reversed by Z-VAD-FMK (Z-VA-DL-D(OMe)-FMK; Item No. 27421), ferrostatin-1 (Item No. 17729), liproxstatin-1 (Item No. 17730), deferoxamine (DFO; Item No. 14595), necrosulfonamide (Item No. 20844), or bafilomycin A1 (Item No. 11038). In vivo, W1131 (10 mg/kg) decreases tumor volume and weight in 5-fluorouracil-sensitive and -resistant MGC803 gastric cancer mouse xenograft models.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Ouyang, S., Li, H., Lou, L., et al. Inhibition of STAT3-ferroptosis negative regulatory axis suppresses tumor growth and alleviates chemoresistance in gastric cancer. Redox Biol. 52:102317, (2022).