A MEK5 inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

MEK Inhibitor

Item No. 43190

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3Z)-3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N-methyl-2-oxo-1H-indole-6-carboxamide
CAS Number
334951-92-7
Synonyms
  • BIX02189
Molecular Formula
C26H26N4O2
Formula Weight
426.5
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
O=C(N1)/C(C(C1=C2)=CC=C2C(NC)=O)=C(C3=CC=CC=C3)\NC4=CC(CN(C)C)=CC=C4
InChi Code
InChI=1S/C26H26N4O2/c1-27-25(31)19-12-13-21-22(15-19)29-26(32)23(21)24(18-9-5-4-6-10-18)28-20-11-7-8-17(14-20)16-30(2)3/h4-15,28H,16H2,1-3H3,(H,27,31)(H,29,32)/b24-23-
InChi Key
BQNHHYZMVCQLJG-VHXPQNKSSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $109

    Add

    5 mg

    $300

    Add

    10 mg

    $436

    Add

    25 mg

    $681

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    MEK inhibitor is an inhibitor of MEK5 (IC50 = 1.5 nM).1 It is selective for MEK5 over ERK5, activin receptor-like kinase 5 (ALK5), also known as TGF-β receptor type I (TGF-βRI), MEK1, and MEK2 (IC50s = 59, 580, >6,300, and >6,300 nM, respectively) and a panel of 79 other kinases at 10 µM. MEK inhibitor (1, 3, or 10 µM) decreases the levels of phosphorylated ERK5 in sorbitol-stimulated HeLa cells. It inhibits TGF-β1-induced increases in N-cadherin levels, decreases in E-cadherin levels, and cell migration in a scratch assay in A549 lung cancer cells when used at a concentration of 10 µM.2 MEK inhibitor (20 mg/kg per day) decreases the number of lung nodules in an A549 mouse model of lung metastasis.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Park, S.J., Choi, Y.S., Lee, S., et al. BIX02189 inhibits TGF-β1-induced lung cancer cell metastasis by directly targeting TGF-β type I receptor. Cancer Lett. 381(2), 314-322 (2016).