A PEGylated derivative of DSPE
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DSPE-PEG(2000)-Azide (sodium salt)

Item No. 43268

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
α-[(9R)-6-hydroxy-6-oxido-1,12-dioxo-9-[(1-oxooctadecyl)oxy]-5,7,11-trioxa-2-aza-6-phosphanonacos-1-yl]-ω-(2-azidoethoxy)-poly(oxy-1,2-ethanediyl), monosodium salt
Synonyms
  • 1,2-DSPE-PEG(2000)-azide
  • 1,2-Distearoyl-sn-glycero-3-PE-Polyethylene Glycol-2000-azide
  • 1,2-Distearoyl-sn-glycero-3-Phosphoethanolamine-N-[azido(Polyethylene Glycol)-2000]
  • azide-DSPE-PEG2000
  • DSPE-PEG2k-azide
Molecular Formula
(C2H4O)nC44H85N4O10P • Na
Formula Weight
942.2
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Slightly soluble: 0.1-1 mg/mlEthanol: Slightly soluble: 0.1-1 mg/ml
SMILES
CCCCCCCCCCCCCCCCCC(OC[C@H](COP(O)(OCCNC(OCCOCCN=[N+]=[N-])=O)=O)OC(CCCCCCCCCCCCCCCCC)=O)=O.[Na+]
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    1 mg

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    Product Description

    DSPE-PEG(2000)-azide is a PEGylated derivative of 1,2-distearoyl-sn-glycero-3-PE (1,2-DSPE; Item No. 15095). It has been used in copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) and copper-free click chemistry, including strain-promoted alkyne-azide cycloaddition (SPAAC).1,2 DSPE-PEG(2000)-azide has been used to attach vascular cell adhesion molecule-1 (VCAM-1) antibodies to the surface of liposomes encapsulating fingolimod (Item Nos. 11975 | 10006292) to provide targeted delivery of fingolimod to inflamed vasculature in a mouse model of post-stroke neuroinflammation.3 It has also been used to attach fibrinogen mimetic peptide (FMP) to the surface of synthetic platelets used in a mouse model of liver injury-induced uncontrolled hemorrhage.4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. D’Acunzo, F., Carbonaro, L., Cort, A.D., et al. Click‐connected 2‐(hydroxyimino)aldehydes for the design of UV‐responsive functional molecules. Eur. J. Org. Chem. 2, 289-294 (2021).

    2. Xiao, Y., Liu, Q., Clulow, A.J., et al. PEGylation and surface functionalization of liposomes containing drug nanocrystals for cell-targeted delivery. Colloids Surf. B Biointerfaces 182, 110362 (2019).

    3. Zaleski, M.H., Omo-Lamai, S., Nong, J., et al. Nanocarriers' repartitioning of drugs between blood subcompartments as a mechanism of improving pharmacokinetics, safety, and efficacy. J. Control. Release 374, 425-440 (2024).

    4. Dyer, M.R., Hickman, D., Luc, N., et al. Intravenous administration of synthetic platelets (SynthoPlate) in a mouse liver injury model of uncontrolled hemorrhage improves hemostasis. J. Trauma Acute Care Surg. 84(6), 917-923 (2018).