A BET inhibitor
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ZEN-3694

Item No. 43661

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
6-(3,5-dimethyl-4-isoxazolyl)-N-methyl-1-(phenylmethyl)-1H-imidazo[4,5-b]pyridin-2-amine
CAS Number
1643947-30-1
Molecular Formula
C19H19N5O
Formula Weight
333.4
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥ 10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
CNC1=NC(N=CC(C2=C(C)ON=C2C)=C3)=C3N1CC4=CC=CC=C4
InChi Code
InChI=1S/C19H19N5O/c1-12-17(13(2)25-23-12)15-9-16-18(21-10-15)22-19(20-3)24(16)11-14-7-5-4-6-8-14/h4-10H,11H2,1-3H3,(H,20,21,22)
InChi Key
VUFGOHIETLJZRG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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Certificates of Analysis & Batch Specific Data

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    1 mg

    $42

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    5 mg

    $189

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    10 mg

    $335

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    25 mg

    $576

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    Cayman Chemical
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    Product Description

    ZEN-3694 is an inhibitor of the bromodomain and extra terminal domain (BET) family of proteins.1,2 It induces apoptosis in wild-type MCF-7 cells and those resistant to palbociclib (PD 0332991; Item No. 16273) when used at a concentration of 1 µM.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Feng, Y., Mahdi, H., Piekarz, R., et al. An LC-MS/MS method for determination of the bromodomain inhibitor ZEN-3694 and its metabolite ZEN-3791 in human plasma. Bioanalysis 16(8), 227-238 (2024).

    2. Kharenko, O.A., Patel, R.G., Calosing, C., et al. Combination of ZEN-3694 with CDK4/6 inhibitors reverses acquired resistance to CDK4/6 inhibitors in ER-positive breast cancer. Cancer Gene Ther. 29(6), 859-869 (2022).