An internal standard for the quantification of uric acid
Related Products
Unlabeled Version(s)
16219Uric Acid (sodium salt)
Technical Support & Resources

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Uric Acid-13C,15N3

Item No. 44020

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,9-dihydro-1H-purine-2,6,8(3H)-trione-2-13C-1,3,7-15N3
CAS Number
2421217-23-2
Molecular Formula
C4[13C]H4N[15N]3O3
Formula Weight
172.1
Purity
≥95%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Water: Soluble
SMILES
O=[13C]([15NH]C(N1)=C2[15NH]C1=O)[15NH]C2=O
InChi Code
InChI=1S/C5H4N4O3/c10-3-1-2(7-4(11)6-1)8-5(12)9-3/h(H4,6,7,8,9,10,11,12)/i5+1,6+1,8+1,9+1
InChi Key
LEHOTFFKMJEONL-CIKYWDRWSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $1,095

    Add
    Cayman Chemical
    Explore Obesity & Metabolic Disease Resources

    Discover high-quality research tools to investigate GLP-1 mechanisms and next-generation metabolic targets.

    OBESITY RESEARCH SOLUTIONS
    Product Description

    Uric acid-13C,15N3 is intended for use as an internal standard for the quantification of uric acid (Item No. 16219) by GC- or LC-MS. Uric acid is a ubiquitous end product of purine metabolism in humans that is mainly excreted in urine, whereas in other mammals it is further metabolized to allantoin by uricase.1 The final two steps in its production are catalyzed by xanthine oxidase, which generates superoxide.2 Uric acid acts as a potent peroxynitrite scavenger and antioxidant.1,2,3 However, high levels of serum uric acid (>120 µg/ml), termed hyperuricemia, are associated with gout, kidney stones, metabolic syndrome, hypertension, renal disease, and cardiovascular disease.1,4,5,6,7 Uric acid, in its soluble form, increases IL-1β levels in bone marrow-derived macrophages (BMDMs) in a manner dependent on NOD-like receptor protein 3 (NLRP3) and myeloid differentiation factor 88 (MyD88).8 It also increases proteinuria and induces renal collagen deposition in a mouse model of obstructive nephropathy, effects that can be reduced by allopurinol (Item No. 10012597).

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alvarez-Lario, B., and Macarrón-Vicente, J. Is there anything good in uric acid? QJM 104(12), 1015-1024 (2011).

    2. Glantzounis, G.K., Tsimoyiannis, E.C., Kappas, A.M., et al. Uric acid and oxidative stress. Curr. Pharm. Des. 11(32), 4145-4151 (2005).

    3. Hooper, D.C., Spitsin, S., Kean, R.B., et al. Uric acid, a natural scavenger of peroxynitrite, in experimental allergic encephalomyelitis and multiple sclerosis. Proc. Natl. Acad. Sci. USA 95, 675-680 (1998).

    4. Watanabe, S., Kang, D.H., Feng, L., et al. Uric acid, hominoid evolution, and the pathogenesis of salt-sensitivity. Hypertension 40(3), 355-360 (2002).

    5. Dehghan, A., van Hoek, M., Sijbrands, E.J.G., et al. High serum uric acid as a novel risk factor for type 2 diabetes. Diabetes Care 31(2), 361-362 (2008).

    6. Heinig, M., and Johnson, R.J. Role of uric acid in hypertension, renal disease, and metabolic syndrome. Cleve. Clin. J. Med. 73(12), 1059-1064 (2006).

    7. Nakagawa, T., Hu, H., Zharikov, S., et al. A causal role for uric acid in fructose-induced metabolic syndrome. Am. J. Physiol. Renal Physiol. 290(3), F625-F631 (2006).

    8. Braga, T.T., Forni, M.F., Correa-Costa, M., et al. Soluble uric acid activates the NLRP3 inflammasome. Sci. Rep. 7, 39884 (2017).