A peptide fragment of substance P
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Substance P (8-11) (trifluoroacetate salt)

Item No. 44038

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(S)-2-(2-((S)-2-amino-3-phenylpropanamido)acetamido)-N-((S)-1-amino-4-(methylthio)-1-oxobutan-2-yl)-4-methylpentanamide, trifluoroacetate salt
Synonyms
  • Phe-Gly-Leu-Met
  • SP (8-11)
Molecular Formula
C22H35N5O4S • XCF3COOH
Formula Weight
465.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
FGLM-NH2
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Slightly soluble: 0.1-1 mg/ml
SMILES
CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CNC([C@@H](N)CC1=CC=CC=C1)=O)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C22H35N5O4S.C2HF3O2/c1-14(2)11-18(22(31)27-17(20(24)29)9-10-32-3)26-19(28)13-25-21(30)16(23)12-15-7-5-4-6-8-15;3-2(4,5)1(6)7/h4-8,14,16-18H,9-13,23H2,1-3H3,(H2,24,29)(H,25,30)(H,26,28)(H,27,31);(H,6,7)/t16-,17-,18-;/m0./s1
InChi Key
LFNCTBJROMLLTO-UVJOBNTFSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

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    1 mg

    $28

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    5 mg

    $125

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    10 mg

    $207

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    25 mg

    $379

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Substance P (8-11) is a peptide fragment of substance P (Item No. 24035).1 It promotes corneal epithelial wound healing in combination with insulin-like growth factor 1 (IGF-1) in diabetic rats with streptozotocin-induced diabetes. Inner ear infusion of substance P (8-11), in combination with the IGF-1 tetrapeptide SSSR, increases the number of lateral circular canal synaptic ribbons, decreases the incidence of spontaneous nystagmus, and stabilizes the vestibulo-ocular reflex in a guinea pig model of vestibular disorder induced by (R,S)-AMPA (Item No. 14571).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Nakamura, M., Kawahara, M., Morishige, N., et al. Promotion of corneal epithelial wound healing in diabetic rats by the combination of a substance P-derived peptide (FGLM-NH2) and insulin-like growth factor-1. Diabetologia 46(6), 839-842 (2003).

    2. Toyota, H., Shimogori, H., Sugahara, K., et al. A novel treatment for vestibular disorder with FGLM-NH2 plus SSSR. Neurosci. Lett. 526(2), 128-132 (2012).