A PEGylated and clickable form of DSPE
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

DSPE-PEG(2000)-DBCO

Item No. 44696

Product Insert (PDF)
Technical Information
CAS Number
1895854-56-4
Synonyms
  • 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[dibenzocyclooctyl(polyethylene glycol)-2000]
  • DSPE-PEG2000-DBCO
  • DSPE-PEG(2000)-dibenzocyclooctyne
Molecular Formula
(C2H4O)nC63H100N3O12P
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Soluble: ≥ 10 mg/ml
SMILES
CCCCCCCCCCCCCCCCCC(O[C@@H](COP(OCCNC(OCCOCCNC(CCC(N1C2=C(C#CC3=C(C1)C=CC=C3)C=CC=C2)=O)=O)=O)(O)=O)COC(CCCCCCCCCCCCCCCCC)=O)=O
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    5 mg

    $110

    Add

    10 mg

    $209

    Add
    Cayman Chemical
    Visit Our Lipid Nanoparticle Resource Center for Additional Tools & Resources
    EXPLORE NOW
    Product Description

    DSPE-PEG(2000)-DBCO is a PEGylated and clickable form of 1,2-distearoyl-sn-glycero-3-PE (1,2-DSPE; Item No. 15095) that has been used in the formation of liposomes and lipid nanodiscs.1,2 It has been used in the generation of liposome-anchored macrophages for the delivery of a cholesterol-conjugated toll-like receptor 7/8 (TLR7/8) agonist to activate them into M1-like macrophages, which phagocytose 4T1 breast cancer cells in vitro.1 Lipid nanodiscs containing DSPE-PEG(2000)-DBCO have been conjugated to a clickable form of DOTA (Item No. 43655) and radiolabeled with copper-64 (64Cu) for PET imaging of tumors in mice.2 DSPE-PEG(2000)-DBCO has also been used as a reactive anchor lipid by direct incorporation into the plasma membranes of RAW 264.7 cells.3

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Yoo, Y.J., Eun, R., Park, H.M., et al. Nanoengineered macrophages armed with TLR7/8 agonist enhance remodeling of immunosuppressive tumor microenvironment. Small 20(13), e2307694 (2024).

    2. Wong, P., Li, L., Chea, J., et al. Antibody targeted pet imaging of 64Cu-DOTA-anti-cea pegylated lipid nanodiscs in CEA positive tumors. Bioconjug. Chem. 31(3), 743-753 (2020).

    3. Vabbilisetty, P., Boron, M., Nie, H., et al. Chemical reactive anchoring lipids with different performance for cell surface re-engineering application. ACS Omega 3(2), 1589-1599 (2018).