An Analytical Reference Standard
Related Products
Alternative(s)
36303Orphine
Metabolite(s)
37339nor-Orphine
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Orphine (hydrochloride)

Item No. 45279

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
1,3-dihydro-1-[1-(1-phenylethyl)-4-piperidinyl]-2H-benzimidazol-2-one, monohydrochloride
Molecular Formula
C20H23N3O • HCl
Formula Weight
357.9
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/ml
SMILES
CC(C1=CC=CC=C1)N2CCC(N3C(NC4=C3C=CC=C4)=O)CC2.Cl
InChi Code
InChI=1S/C20H23N3O.ClH/c1-15(16-7-3-2-4-8-16)22-13-11-17(12-14-22)23-19-10-6-5-9-18(19)21-20(23)24;/h2-10,15,17H,11-14H2,1H3,(H,21,24);1H
InChi Key
DVHXKHIUWSQNFT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    Product Description

    Orphine (hydrochloride) (Item No. 45279) is an analytical reference standard categorized as an opioid.1,2 Orphine induces antinociception in mice that is reduced by naloxone (Item Nos. ISO60191 | 15594).2 This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Kennedy, N.M., Schmid, C.L., Ross, N.C., et al. Optimization of a series of mu opioid receptor (MOR) agonists with high G protein signaling bias. J. Med. Chem. 61(19), 8895-8907 (2018).

    2. Vandeputte, M.M., Bilel, S., Tirri, M., et al. Elucidating the harm potential of brorphine analogues as new synthetic opioids: Synthesis, in vitro, and in vivo characterization. Neuropharmacology 260, 110113 (2024).