A FAK inhibitor
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Narmafotinib

Item No. 45335

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-[2-[2-[[2-methoxy-4-(1-methyl-4-piperidinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]ethyl]-benzeneacetamide
CAS Number
1393653-34-3
Synonyms
  • AMP945
  • CTx-0294945
Molecular Formula
C28H32F3N5O2
Formula Weight
527.6
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
Acetonitrile:Water (1:1): Slightly soluble: 0.1-1 mg/ml
SMILES
FC(F)(F)C1=CN=C(NC2=CC=C(C3CCN(CC3)C)C=C2OC)N=C1CCC4=C(CC(N)=O)C=CC=C4
InChi Code
InChI=1S/C28H32F3N5O2/c1-36-13-11-19(12-14-36)21-8-10-24(25(15-21)38-2)35-27-33-17-22(28(29,30)31)23(34-27)9-7-18-5-3-4-6-20(18)16-26(32)37/h3-6,8,10,15,17,19H,7,9,11-14,16H2,1-2H3,(H2,32,37)(H,33,34,35)
InChi Key
AWJVIOYPZZZYAX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $55

    Add

    5 mg

    $248

    Add

    10 mg

    $385

    Add
    Kinase Resource Center
    Discover Products & Resources for Kinase Research
    • Kinase inhibitors, screening libraries, assay kits, & more
    • Tools to study kinase signaling pathways:
      • Growth factor signaling
      • PI3K/Akt/mTOR
      • MAPKs (ERK, p38, & JNK)
      • JAK/STAT signaling
    • Articles, resources, & advice
    EXPLORE NOW
    Product Description

    Narmafotinib is an inhibitor of focal adhesion kinase (FAK).1 It inhibits autophosphorylation of FAK at tyrosine 397 in MDA-MB-231 breast cancer cells (IC50 = 7 nM). Narmafotinib (80 mg/kg), in combination with bevacizumab, reduces tumor growth in an MDA-MB-231 orthotopic mouse model of breast cancer. It also induces intratumoral apoptosis, reduces tumor growth, and increases survival in subcutaneous and orthotopic patient-derived xenograft (PDX) mouse models of pancreatic cancer when administered at a dose of 10 mg/kg in a cycle with the FOLFIRINOX regimen, which includes leucovorin, 5-fluorouracil (Item No. 14416), irinotecan (Item No. 14180), and oxaliplatin (Item No. 13106).2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Street, I., de Sylva, M., Lackovic, K., et al. Abstract LB-308: Combination of CTx-0294945 a highly selective inhibitor of focal adhesion kinase with bevacizumab in pre-clinical models of breast cancer. Cancer Res. 72(8_Supplement), (2012).

    2. Burns, C., Murphy, K., Cock, T.-A., et al. The effect of adding a selective FAK inhibitor AMP945 to FOLFIRINOX in a model of pancreatic cancer. J. Clin. Oncol. 41(16_Suppl), (2023).