A glucokinase activator
Related Products
Diastereomer(s)
43205Sinogliatin
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Dorzagliatin

Item No. 46210

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-(2-chlorophenoxy)-N-[1-[(2R)-2,3-dihydroxypropyl]-1H-pyrazol-3-yl]-2,5-dihydro-αS-(2-methylpropyl)-2-oxo-1H-pyrrole-1-acetamide
CAS Number
1191995-00-2
Synonyms
  • HMS5552
  • RO5305552
  • Sinogliatin
Molecular Formula
C22H27ClN4O5
Formula Weight
462.9
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Soluble: ≥10 mg/mlEthanol: Sparingly soluble: 1-10 mg/ml
SMILES
O=C(NC1=NN(C[C@@H](O)CO)C=C1)[C@H](CC(C)C)N2C(C=C(OC3=CC=CC=C3Cl)C2)=O
InChi Code
InChI=1S/C22H27ClN4O5/c1-14(2)9-18(22(31)24-20-7-8-26(25-20)11-15(29)13-28)27-12-16(10-21(27)30)32-19-6-4-3-5-17(19)23/h3-8,10,14-15,18,28-29H,9,11-13H2,1-2H3,(H,24,25,31)/t15-,18+/m1/s1
InChi Key
HMUMWSORCUWQJO-QAPCUYQASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $79

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    10 mg

    $134

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    25 mg

    $296

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    50 mg

    $435

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    Dorzagliatin is an activator of glucokinase.1 It increases hepatic levels of glucokinase and pancreatic levels of insulin in a rat model of diabetes induced by streptozotocin (Item No. 13104) and a high-fat diet (HFD) when administered at doses of 10 or 30 mg/kg per day. Dorzagliatin (10 or 30 mg/kg) decreases blood levels of glucose in an oral glucose tolerance test (OGTT) in the same model. Formulations containing dorzagliatin have been used in the treatment of type 2 diabetes.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Wang, P., Liu, H., Chen, L., et al. Effects of a novel glucokinase activator, HMS5552, on glucose metabolism in a rat model of type 2 diabetes mellitus. J. Diabetes Res. 5812607 (2017).