A BSA complex with linoleic acid
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BSA-Linoleate ω-6 Polyunsaturated Fatty Acid Complex (5 mM)

Item No. 46461

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Synonyms
  • Bovine Serum Albumin-LA
  • Bovine Serum Albumin-Linoleate
  • BSA-LA
  • BSA-9(Z),12(Z)-Octadecadienoic Acid
Formulation (Request formulation change)
5 mM linoleate:0.8 mM BSA in 150 mM sodium chloride
Origin
Animal/Bovine
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

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    5 ml

    $162

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    Product Description

    BSA-Linoleate ω-6 Polyunsaturated Fatty Acid Complex (5 mM) is composed of linoleic acid (Item No. 90150) and fatty acid-free bovine serum albumin (BSA) at an approximately 6:1 molar ratio of linoleate:BSA. It was prepared under sterile conditions, then filtered and aliquoted into sterile vials. Cayman's BSA-Linoleate ω-6 Polyunsaturated Fatty Acid Complex (5 mM) can be used for efficient fatty acid delivery to cells in culture as a source of essential nutrients to support cell growth in serum-free or reduced-serum media. It can also be used for the purpose of monitoring lipid metabolism and inflammatory signaling pathways, as linoleic acid is a precursor to arachidonic acid and downstream inflammatory lipid mediators.1,2,3,4,5 Cayman's BSA-Linoleate ω-6 Polyunsaturated Fatty Acid Complex (5 mM) is suitable for use in short- and long-term cell culture applications (25+ hours). This product can be used to achieve higher concentrations or perform larger experiments than can be achieved with BSA-Linoleate ω-6 Polyunsaturated Fatty Acid Complex (1 mM) (Item No. 38649). For best results, it is recommended that this product be used in conjunction with Cayman's BSA Control for BSA-Fatty Acid Complexes (5 mM) (Item No. 29556), prepared with fatty acid-free BSA.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Alsabeeh, N., Chausse, B., Kakimoto, P.A., et al. Cell culture models of fatty acid overload: Problems and solutions. Biochim. Biophys. Acta Mol. Cell Biol. Lipids 1863(2), 143-151 (2018).

    2. Menon, D., Salloum, D., Bernfeld, E., et al. Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid. The Journal of Biological Chemisty 292(15), 6303-6311 (2017).

    3. Wiesenfeld, P.W., Babu, U.S., and O'Donnell, M.W. Effect of long-chain fatty acids in the culture medium on fatty acid composition of WEHI-3 and J774A.1 cells. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 128(1), 123-134 (2001).

    4. Colquhoun, A., and Curi, R. Regulation of tumour cell fatty acid oxidation by n-6 polyunsaturated fatty acids. Biochem. Soc. Trans. 25(4), S681 (1997).

    5. Mukherjee, A., Adhikari, A., Das, P., et al. Loss of virulence in NAD(P)H cytochrome b5 oxidoreductase deficient Leishmania major. Biochem. Biophys. Res. Commun. 503(1), 371-377 (2018).