An internal standard for the quantification of 1,3,7-trimethyluric acid
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Unlabeled Version(s)
169491,3,7-Trimethyluric Acid
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1,3,7-Trimethyluric Acid-d9

Item No. 9003567

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
7,9-dihydro-1,3,7-tri(methyl-d3)-1H-purine-2,6,8(3H)-trione
CAS Number
117490-42-3
Synonyms
  • TMU-d9
  • 8-oxo Caffeine-d9
Molecular Formula
C8HD9N4O3
Formula Weight
219.2
Purity
≥99% deuterated forms (d1-d9)
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 10 mg/mlDMSO: 10 mg/mlEthanol: 1 mg/mlPBS (pH 7.2): 1 mg/ml
λmax
236, 290 nm
SMILES
O=C(N(C1=O)C([2H])([2H])[2H])C(N(C(N2)=O)C([2H])([2H])[2H])=C2N1C([2H])([2H])[2H]
InChi Code
InChI=1S/C8H10N4O3/c1-10-4-5(9-7(10)14)11(2)8(15)12(3)6(4)13/h1-3H3,(H,9,14)/i1D3,2D3,3D3
InChi Key
BYXCFUMGEBZDDI-GQALSZNTSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
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    Product Description

    1,3,7-Trimethyluric acid-d9 is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid (Item No. 16949) by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid (Item No. 16219) and a metabolite of caffeine (Item No. 14118).1 It is formed from caffeine by the cytochrome P450 (CYP) isoform CYP3A4. 1,3,7-Trimethyluric acid (500 µM) scavenges hydroxyl radicals in a cell-free assay and inhibits t-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Tassaneeyakul, W., Birkett, D.J., McManus, M.E., et al. Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoforms. Biochem. Pharmacol. 47(10), 1767-1776 (1994).

    2. Bhat, V.B., Sridhar, G.R., and Madyastha, K.M. Efficient scavenging of hydroxyl radicals and inhibition of lipid peroxidation by novel analogues of 1,3,7-trimethyluric acid. Life Sci. 70(4), 381-393 (2001).