An isomer of linoleic acid
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9(Z),11(E)-Conjugated Linoleic Acid

Item No. 90140

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
9Z,11E-octadecadienoic acid
CAS Number
2540-56-9
Synonyms
  • 9Z,11E-CLA
  • cis-9,trans-11-Conjugated Linoleic Acid
  • FA 18:2
Molecular Formula
C18H32O2
Formula Weight
280.5
Purity
≥98%
Formulation
A solution in ethanol
Solubility(Learn about Variance in Solubility)
0.15 M Tris-HCl pH 8.5: >1 mg/ml (from Oleic Acid)DMF: >100 mg/ml (from Oleic Acid)DMSO: >100 mg/ml (from Oleic Acid)Ethanol: >100 mg/ml (from Oleic Acid)PBS pH 7.2: <100 µg/ml (from Oleic Acid)
λmax
233 nm
SMILES
CCCCCC/C=C/C=C\CCCCCCCC(O)=O
InChi Code
InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h7-10H,2-6,11-17H2,1H3,(H,19,20)/b8-7+,10-9-
InChi Key
JBYXPOFIGCOSSB-GOJKSUSPSA-N
Side Chain Carbon Sum
18:2
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 mg

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    Product Description

    9(Z),11(E)-Conjugated linoleic acid is an isomer of linoleic acid (Item Nos. 90150 | 90150.1 | 21909) that has been found in beef and milk fat.1 It binds to peroxisome proliferator-activated receptor α (PPARα; IC50 = 140 nM) and activates the receptor in a reporter assay using COS-1 cells expressing mouse PPARα when used at a concentration of 100 µM.2 9(Z),11(E)-Conjugated linoleic acid inhibits TNF-α-induced GLUT4 expression and increases insulin-stimulated glucose transport in 3T3-L1 adipocytes.3 Dietary administration of 9(Z)11(E)-conjugated linoleic acid reduces serum fasting glucose, insulin, and triglyceride levels and decreases white adipose tissue macrophage infiltration in ob/ob mice. It also increases body weight gain and body fat in weanling mice.4 [Matreya, LLC. Catalog No. 1245]

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Shultz, T.D., Chew, B.P., Seaman, W.R., et al. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and β-carotene on the in vitro growth of human cancer cells. Cancer Lett. 63(2), 125-133 (1992).

    2. Moya-Camarena, S.Y., Heuvel, J.P.V., Blanchard, S.G., et al. Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARα. J. Lipid Res. 40(8), 1426-1433 (1999).

    3. Moloney, F., Toomey, S., Noone, E., et al. Antidiabetic effects of cis-9, trans-11-conjugated linoleic acid may be mediated via anti-inflammatory effects in white adipose tissue. Diabetes 56(3), 574-582 (2007).

    4. Pariza, M.W., Park, Y., and Cook, M.E. The biologically active isomers of conjugated linoleic acid. Prog. Lipid Res. 40(4), 283-298 (2001).

    Product Citations

    Zhang, L.J., Salekeen, R., Soto-Palma, C., et al. Article polyunsaturated lipid senolytics exploit a ferroptotic vulnerability in senescent cells. Cell Press Blue 1(1), 100004 (2026).