Helping Make Your Cancer Research Possible

In their landmark publication in Cell in 2000, Hanahan and Weinberg first defined six hallmarks of cancer, characteristics that facilitate the survival, proliferation, and dissemination of cancer cells. This number has since grown to include ten hallmarks, as well as four enabling characteristics that foster the acquisition of these hallmarks. Cayman offers a wide range of tools, resources, and services to investigate the hallmarks and enabling characteristics of cancer, increase our understanding of cancer biology and oncogenesis, and promote advances in anticancer therapeutic development.

Explore our Cancer Cell Signaling & Regulation page to learn more about cellular signaling pathways and regulatory mechanisms that contribute to the enabling characteristics of epigenetic reprogramming and genome mutation, as well as cancer hallmarks including sustained proliferative signaling, cell death resistance, and senescence.

Visit our Cancer Metabolism page for information on various metabolic processes that are altered in cancer cells.

View the Tumor Microenvironment page to find out more about how cancer cells interact with the immune system, vascular system, and metastasize to secondary sites.