Targeting cGAS Activity in the STING Pathway: Assays for Drug Discovery
Inhibiting cGAS activity can decrease type I IFN production, which could provide a novel way to treat autoimmune diseases.
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Inhibiting cGAS activity can decrease type I IFN production, which could provide a novel way to treat autoimmune diseases.
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Abnormal expression of this Neu5Gc-containing ganglioside has been established as a cancer biomarker.
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Growth factor signaling regulates numerous cellular processes, including differentiation, survival, migration, and proliferation.
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Cellular glycosylation profiles can affect cell recognition, inter- and intracellular signaling, cell adhesion, and cell-cell interactions. Changes in the expression of cell surface carbohydrates have been associated with oncogenesis.
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A DNA damage response can be targeted to activate STING. PARP inhibitors disrupt DNA damage repair allowing DNA to accumulate in the tumor cell cytosol...
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Heat shock response is an immediate and highly conserved reprogramming of cellular activities in riposte to stress.
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Chemical probes are well-characterized small molecules that potently and selectively modulate target protein activity. Use this guide to help you choose the best chemical probe for your experiments.
Download GuideThis application note demonstrates the power of combining Seahorse XFe96 technology with manipulation of the major mitochondrial fuel pathways.
Download App NoteWe offer a range of probes to detect intracellular events, protein interactions, a host of enzyme substrates, and many other significant targets. Use this at-a-glance guide to select the most appropriate fluorochromes for your experiment.
Download BrochureIn this app note, mitochondrial stress, fatty acid oxidation stress, and mitochondrial fuel flexibility tests reveal how metabolic phenotype can vary based on culture conditions.
Download App NoteThe signal transduction pathways responsible for virtually every cell function in the body are built on a network of kinases. Use the signal transduction cascades inside this brochure to explore inhibitors targeting specific nodes...
Download BrochureAn optimized workflow for the sensitive and specific analysis of MHC-I peptides, using HCT116 as a case study, is presented.
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