A DEA Form 222 is necessary for the purchase of Schedule I or II controlled substances. We have provided step-by-step instructions to prepare and mail your DEA form 222 to Cayman Chemical.

Updated October 2025

Nitazenes are one of several types of novel analgesics developed in the 20th century as potential alternatives to traditional opiates. Since first appearing on the illicit market in 2018, several novel 2-benzylbenzimidazole opioids have emerged as novel psychoactive substances (NPS). These compounds are structurally different from fentanyl and most are not well characterized, but some have been reported to cause physiological effects similar to heroin, fentanyl, and other opioids. Dozens of nitazene analogs have now been identified in circulation across the world, further complicating efforts to monitor and understand their pharmacological profiles. This NPS Snapshot summarizes structures of various nitazene compounds as well as key historical dates, prototypical structure, and known pharmacology.

Learn more in our recent webinar: Making a splash: Nitazenes and Orphines, the latest wave of opioid NPS.

To cite this NPS snapshot: Iula, D.M., St. Germaine, D.M., and Layle, N.K. NPS snapshot: nitazenes. Cayman Chemical (September 2020).

​As more analytical laboratories involved in Cannabis testing fall under regulatory and/or accreditation requirements, they are expected to utilize CRMs when available. This article outlines several production steps Cayman considers when creating a CRM to address questions frequently heard from our customers about how compounds are selected to be made into CRMs and how long it takes to produce them. 

This article was first published in the July/August issue of Terpenes and Testing.

​Want to streamline your Cannabis potency testing and cannabinoid profiling? Watch how different reference standard preparation methods stack up and see why testing labs are implementing Cayman’s pre-made, multi-component CRM mixtures into their workflows. Cayman offers a suite of CRM mixtures for mass spectrometry applications. The Phytocannabinoid 10 Mixture (CRM) featured in this video contains ten phytocannabinoids prevalent in Cannabis.

Access the data in our application note: CRM Mixtures Improve Quantitation Accuracy.

​Delivery time of controlled reference materials requires the careful navigation of governmental agencies of both the country of origin and country of import. Several processes are in place to document the transfer of goods and additional steps are needed if the compound is recognized as an internationally or locally controlled substance. Review the procedures and estimated timeline for the export/import of controlled substances.

​Fentanyl (hydrochloride) (CRM) and all fentanyl analogs (provided as neat materials) used in the study are Cayman products. Single component solutions for each fentanyl analog were prepared by dissolving 1 mg of neat material in 1 ml of HPLC-grade methanol (EMD Millipore). Twenty multicomponent mixtures were prepared by transferring 200 μl aliquots of each single component solution with a 200 μl aliquot of internal standard into a vial and dried under nitrogen. The multicomponent mixtures were reconstituted with 200 μl of methanol for a final nominal concentration of 1.0 mg/ml per component. The multicomponent solutions were transferred to autosampler vials with insert prior to injection. The 20 multicomponent mixtures were used in the GC separation study.