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Pathways for Sphingolipid Synthesis
Pathways for Sphingolipid Synthesis
Article from 2017-04-13
Ceramides and other sphingolipids reside in the outer leaflet of the cell membrane where they modulate cell-cell interactions and can regulate differentiation, proliferation, and programmed cell death. Ceramide is the intermediate in the formation of multiple types of sphingolipids: sphingosine, sphingomyelin, ceramide-1-phosphate, glucosylceramide, and galactosylceramide, each of which mediate a wide range of biological activities. To help you study distinct aspects of this important lipid signaling pathway, Cayman carries many different ceramide and sphingolipid standards as well as inhibitors for the various enzymes driving key events in sphingolipid metabolism.
Download the Primary Pathways for Sphingolipid Synthesis Brochure (PDF)
Analytical Reference Standards
- More than 65 ceramide and sphingolipid standards available
- Bulk quantities, custom standards, and custom mixtures also available
- Labeled standards available
| Item No. | Product Name | Summary | Purity |
|---|---|---|---|
| 62510 | C-2 Ceramide | A cell-permeable analog of naturally occurring ceramides | ≥98% |
| 62540 | C-8 Ceramide | A ceramide analog metabolized within cells to generate natural ceramides | ≥98% |
| 10681 | C-16 Ceramide | A bioactive ceramide | ≥98% |
| 62547 | C-8 Ceramide-1-phosphate | A short-chain analog of naturally occurring ceramide-1-phosphate | ≥90% |
| 17481 | Ganglioside GD3 (sodium salt) | An acidic glycosphingolipid | ≥98% |
| 15587 | Ganglioside GM3 (sodium salt) | A sialic acid-containing glycosphingolipid | ≥98% |
| 17566 | (E)-2-Hexadecenal | A long-chain fatty aldehyde | ≥95% |
| 10007947 | Lyso-Sphingomyelin | A sphingomyelin lacking an acylated side group | ≥98% |
| 62530 | Nervonic Ceramide | An abundant, naturally occurring ceramide | ≥98% |
| 20338 | Psychosine | A galatoside of sphingosine whose cytotoxic accumulation is associated with Krabbe disease | ≥98% |
| 10007945 | D-erythro-Sphinganine | A sphingolipid pathway intermediate | ≥98% |
| 10007946 | Palmitoyl Sphingomyelin | A C-16 sphingomyelin | ≥98% |
| 62570 | Sphingosine-1-Phosphate | A signaling sphingolipid | ≥98% |
| 10007902 | D-erythro-Sphingosine C-17 | A 17 carbon sphingosine | ≥98% |
| 10007907 | D-erythro-Sphingosine C-18 | A pharmacological tool to probe the activity of protein kinase C | ≥98% |
Assay, Antibodies, and Proteins
| Item No. | Product Name | Summary |
|---|---|---|
| 10009928 | Sphingomyelin Colorimetric Assay Kit | Measure sphingomyelin in plasma and serum |
| 10005260 | Serine Palmitoyltransferase Polyclonal Antibody | Host: Rabbit · Applications: IHC, WB |
| 10006822 | Sphingosine Kinase 1 Polyclonal Antibody | Host: Rabbit · Applications: ICC, WB |
| 10012201 | Sphingosine Kinase 1 Polyclonal FITC Antibody | Host: Rabbit · Applications: FC, IF, WB |
| 10348 | Sphingosine Kinase 1 (human recombinant) | Active, N-terminal His-tagged protein from Sf9 cells |
| 10009237 | Sphingosine Kinase 2 (human recombinant) | Full length, N-terminal His-tagged protein from Sf9 cells |
Fluorescent Probes
| Item No. | Product Name | Summary |
|---|---|---|
| 9000753 | AV-Ceramide | Fluorescently tagged C-10 ceramide used to probe lipid transport |
| 10007958 | C-12 NBD Ceramide | Fluorescent ceramide analog used to measure alkaline and neutral ceramidase activity |
| 10008097 | C-12 NBD-dihydro-Ceramide | Fluorescent ceramide analog that contains a saturated bond in the C-4/C-5 position |
| 20948 | 4-Methylumbelliferyl-β-D-Glucopyranoside | Fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (glucosylceramidase) |
| 16620 | 4-Methylumbelliferyl-N-acetyl-α-D-Neuraminic Acid (sodium salt) | Fluorogenic substrate used to assay neuraminidase activity |
Sphingosine-1-Phosphate Receptor Agonists/Antagonists
Sphingosine can be phosphorylated to form sphingosine-1-phospate (S1P), the ligand for a family of S1P receptors.
| Item No. | Product Name | Summary |
|---|---|---|
| 10005033 | CAY10444 | S1P3 receptor antagonist |
| 16925 | CYM 5442 | S1P1 receptor agonist (EC50 = 1.35 nM) |
| 14667 | CYM 50308 | Selective SIP4 receptor agonist (EC50 = 56 nM) |
| 11975 | Fingolimod | Orally bioavailable S1P receptor modulator |
| 10006292 | FTY720 | Immune modulator that targets S1P receptors Also available: azido-FTY720 (Item No. 10008612) and FTY720 Phosphate (Item No. 10008639) |
| 10009458 | JTE-013 | S1P2 receptor antagonist (IC50s = 17 and 22 nM for human and rat, respectively) |
| 10006440 | SEW2871 | Selective S1P1 receptor receptor agonist |
| 10010992 | W123 | S1P1 receptor antagonist (Ki = 0.69 μM) |
| 10009109 | W146 (trifluoroacetate salt) | S1P1 receptor antagonist (Ki = 77 nM) |
Contact Info
Cayman Chemical1180 East Ellsworth RoadAnn Arbor, Michigan 48108 USAToll Free: (800) 364-9897(USA and Canada only)Fax: (734) 971-3640
