An antiepileptic agent and active metabolite of oxcarbazepine
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10,11-dihydro-10-hydroxy Carbamazepine

Item No. 18467

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
10,11-dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
CAS Number
29331-92-8
Synonyms
  • BIA 2-005
  • 10,11-dihydro-10-hydroxy CBZ
  • ​10,11-hydroxy-10,11 Dihydrocarbamezer
  • GP 47779
  • Licarbazepine
Molecular Formula
C15H14N2O2
Formula Weight
254.3
Purity
≥98%
Formulation
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 25 mg/mlDMSO: 25 mg/mlDMSO:PBS(pH7.2) (1:1): 0.5 mg/mlEthanol: 3 mg/ml
SMILES
NC(N1C2=C(C=CC=C2)CC(O)C3=C1C=CC=C3)=O
InChi Code
InChI=1S/C15H14N2O2/c16-15(19)17-12-7-3-1-5-10(12)9-14(18)11-6-2-4-8-13(11)17/h1-8,14,18H,9H2,(H2,16,19)
InChi Key
BMPDWHIDQYTSHX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $55

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    10 mg

    $104

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    25 mg

    $242

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    50 mg

    $428

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    Product Description

    10,11-dihydro-10-hydroxy Carbamazepine is an antiepileptic agent and active metabolite of the prodrug oxcarbazepine (Item No. 17340).1 It is a racemic mixture of (R)- and (S)-10,11-dihydro-10-hydroxy carbamazepine. (S)-10,11-dihydro-10-hydroxy Carbamazepine protects against seizures induced by maximal electroshock (MES) in rats by 42% while (R)-10,11-dihydro-10-hydroxy carbamazepine only protects against MES-induced seizures by 22.5%.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Benes, J., Parada, A., Figueiredo, A.A., et al. Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J. Med. Chem. 42(14), 2582-2587 (1999).