An Analytical Reference Material
Features
  • This product is qualified as a Reference Material that has been manufactured and tested to meet ISO/IEC 17025 and ISO 17034 international standards
  • This product is intended to be used as an analytical reference standard
  • Bulk material is available for qualified institutions; please contact our sales department for pricing
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4-ANPP

Item No. 18810

Restricted Product (Schedule II)
Product Insert (PDF)GC-MS (PDF)Safety Data Sheet (SDS) (PDF)
Synonyms
Synonyms
  • 4-Aminophenyl-1-phenethylpiperidine
  • 4-Anilino-N-phenethylpiperidine
  • Despropionyl fentanyl
Technical Information
Formal Name
N-phenyl-1-(2-phenylethyl)-4-piperidinamine
CAS Number
21409-26-7
Molecular Formula
C19H24N2
Formula Weight
280.4
Purity
≥98%
Formulation
A neat solid
SMILES
C1(NC2CCN(CCC3=CC=CC=C3)CC2)=CC=CC=C1
InChi Code
InChI=1S/C19H24N2/c1-3-7-17(8-4-1)11-14-21-15-12-19(13-16-21)20-18-9-5-2-6-10-18/h1-10,19-20H,11-16H2
InChi Key
ZCMDXDQUYIWEKB-UHFFFAOYSA-N
Regulatory Information
DEA Schedule
II
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    Product Description

    4-ANPP (Item No. 18810) is an analytical reference material categorized as an opioid metabolite and a precursor in the synthesis of fentanyl (Item Nos. ISO60197 | 22659 | 14719) and other opioids.1,2,3,4,5 4-ANPP is a metabolite of acetyl fentanyl (Item Nos. ISO60128 | ISO00128), butyryl fentanyl (Item Nos. 19734 | 14728), furanyl fentanyl (Item Nos. 19633 | 18705), acrylfentanyl (Item Nos. 23060 | 19312), and fentanyl.1,2,3,4 It has also been found as an impurity in illicit fentanyl preparations.6 4-ANPP is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Watanabe, S., Vikingsson, S., Roman, M., et al. In vitro and in vivo metabolite identification studies for the new synthetic opioids acetylfentanyl, acrylfentanyl, furanylfentanyl, and 4-fluoro-isobutyrylfentanyl. AAPS J. 19(4), 1102-1122 (2017).

    2. Labroo, R.B., Paine, M.F., Thummel, K.E., et al. Fentanyl metabolism by human hepatic and intestinal cytochrome P450 3A4: Implications for interindividual variability in disposition, efficacy, and drug interactions. Drug Metab. Dispos. 25(9), 1072-1079 (1997).

    3. Melent'ev, A.B., Kataev, S.S., and Dvorskaya, O.N. Identification and analytical properties of acetyl fentanyl metabolites. J. Anal. Chem. 70(2), 216-224 (2015).

    4. Steuer, A.E., Williner, E., Staeheli, S.N., et al. Studies on the metabolism of the fentanyl-derived designer drug butyrfentanyl in human in vitro liver preparations and authentic human samples using liquid chromatography-high resolution mass spectrometry (LC-HRMS). Drug Test Anal. 9(7), 1085-1092 (2017).

    5. Pease, J.P., LePine, A.J., and Smith, C.M. Methods for preparing fentanyl and fentanyl intermediates. Patent Application Publication US2013/0281702A1, (2013).

    6. Lurie, I.S., Berrier, A.L., Casale, J.F., et al. Profiling of illicit fentanyl using UHPLC-MS/MS. Forensic Sci. Int. 220(1-3), 191-196 (2012).