A natural phytosterol with diverse biological activities
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Fucosterol

Item No. 21858

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
(3β,24E)-stigmasta-5,24(28)-dien-3-ol
CAS Number
17605-67-3
Synonyms
  • trans-24-ethylidene Cholesterol
Molecular Formula
C29H48O
Formula Weight
412.7
Purity
≥98%
Formulation (Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
DMF: 1 mg/mLEthanol: 0.25 mg/mL
SMILES
C/C=C(C(C)C)\CC[C@@H](C)[C@@]1([H])CC[C@@]2([H])[C@]3([H])CC=C4C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC[C@@]21C
InChi Code
InChI=1S/C29H48O/c1-7-21(19(2)3)9-8-20(4)25-12-13-26-24-11-10-22-18-23(30)14-16-28(22,5)27(24)15-17-29(25,26)6/h7,10,19-20,23-27,30H,8-9,11-18H2,1-6H3/b21-7+/t20-,23+,24+,25-,26+,27+,28+,29-/m1/s1
InChi Key
OSELKOCHBMDKEJ-JUGJNGJRSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    1 mg

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    5 mg

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    10 mg

    $198

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    Cayman Chemical
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    Product Description

    Fucosterol is a plant sterol found in algae that has diverse biological activities including antioxidant, anti-inflammatory, anticancer, and antidiabetic properties among others.1 It decreases markers of oxidative damage and increases antioxidative enzyme activity in vitro.2 It reduces the expression of TNF-α and IL-6 following LPS administration by halting NF-κB and p38 MAPK signaling in RAW 264.7 murine macrophages.3 In HEK293, MCF-7, and SiHa cells, fucosterol decreases proliferation (IC50s = 185.4, 43.3, and 34.0 µg/ml, respectively).4 It also has anticancer activity in HL-60 leukemia cells, where it inhibits cell growth, halts the cell cycle at the G2/M transition, and induces apoptosis with maximally increased caspase-9, -8, and -3 expression at 68.8 µM.5 In a streptozotocin rat model of diabetes, it decreases serum glucose concentrations when administered at 30 mg/kg.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Abdul, Q.A., Choi, R.J., Jung, H.A., et al. Health benefit of fucosterol from marine algae: A review. J. Sci. Food Agric. 96(6), 1856-1866 (2015).

    2. Lee, S., Lee, Y.S., Jung, S.H., et al. Anti-oxidant activities of fucosterol from the marine algae Pelvetia siliquosa. Arch. Pharm. Res. 26(9), 719-722 (2003).

    3. Yoo, M.S., Shin, J.S., Choi, H.E., et al. Fucosterol isolated from Undaria pinnatifida inhibits lipopolysaccharide-induced production of nitric oxide and pro-inflammatory cytokines via the inactivation of nuclear factor-κB and p38 mitogen-activated protein kinase in RAW264.7 macrophages. Food Chem. 135(3), 967-975 (2012).

    4. Caamal-Fuentes, E., Moo-Puc, R., Freile-Pelegrin, Y., et al. Cytotoxic and antiproliferative constituents from Dictyota ciliolata, Padina sanctae-crucis and Turbinaria tricostata. Pharm. Biol. 52(10), 1244-1248 (2014).

    5. Yi, Y.B., Ji, C.F., and Yue, L. Study on human promyelocytic leukemia HL-60 cells apoptosis induced by fucosterol. Biomed. Mater. Eng. 24(1), 845-851 (2014).

    6. Lee, Y.S., Shin, K.H., Kim, B.K., et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa. Arch. Pharm. Res. 27(11), 1120-1122 (2004).