Phosphatidylethanolamine (bovine heart)

Phosphatidylethanolamine is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids.¹ In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is also one of the major phospholipid species in heart inner mitochondrial membranes.² Phosphatidylethanolamine is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial membranes, respectively.¹ It is a precursor in the synthesis of phosphatidylcholine and arachidonoyl ethanolamide (AEA; Item No. 90050) and is a source of ethanolamine used in various cellular functions. When the phosphatidylethanolamine levels in the mitochondria are reduced, mitochondrial morphology is altered and its function is impaired.³ This product contains phosphatidylethanolamine molecular species with primarily C20:4, C18:0, and C18:2 fatty acyl chains.

WARNING This product is not for human or veterinary use.

1. Vance, J.E., and Tasseva, G. Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells. Biochim. Biophys. Acta 1831(3), 543-554 (2013).

2. Comte, J., Mäisterrena, B., and Gautheron, D.C. Lipid composition and protein profiles of outer and inner membranes from pig heart mitochondria. Comparison with microsomes. Biochim. Biophys. Acta 419(2), 271-284 (1976).

3. Vance, J.E. Historical perspective: phosphatidylserine and phosphatidylethanolamine from the 1800s to the present. J. Lipid. Res. 59(6), 923-944 (2018).