A polyphenol with diverse biological activities
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Syringaldehyde

Item No. 33489

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
4-hydroxy-3,5-dimethoxy-benzaldehyde
CAS Number
134-96-3
Synonyms
  • NSC 41153
  • SM 707
  • VND 3207
Molecular Formula
C9H10O4
Formula Weight
182.2
Purity
≥98%
Formulation
A solid
Solubility(Learn about Variance in Solubility)
DMF: 30 mg/mlDMSO: 30 mg/mlDMSO:PBS (pH 7.2) (1:7): 0.12 mg/mlEthanol: 1 mg/ml
λmax
216, 231, 310 nm
SMILES
O=CC1=CC(OC)=C(C(OC)=C1)O
InChi Code
InChI=1S/C9H10O4/c1-12-7-3-6(5-10)4-8(13-2)9(7)11/h3-5,11H,1-2H3
InChi Key
KCDXJAYRVLXPFO-UHFFFAOYSA-N
Origin
Synthetic
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    10 g

    $40

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    50 g

    $132

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    100 g

    $190

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    Product Description

    Syringaldehyde is a polyphenol that has been found in E. granulatus and has diverse biological activities.1,2,3,4 It inhibits LPS-induced COX-2 activity in RAW 264.7 cells with an IC50 value of 19.23 µM.1 Syringaldehyde inhibits the proliferation of HCT116, Caco-2, and HT-29 colon cancer cells (IC50s = 56.3, 35.9, and 68.6 µM, respectively).2 It decreases plasma glucose levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) when administered at doses ranging from 1.8 to 7.2 mg/kg.3 Syringaldehyde (25 and 50 mg/kg) reduces infarct size in a rat model of myocardial infarction induced by isoproterenol (Item No. 15592).4

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Stanikunaite, R., Khan, S.I., Trappe, J.-M., et al. Cyclooxygenase-2 inhibitory and antioxidant compounds from the truffle Elaphomyces granulatus. Phytother. Res. 23(4), 575-578 (2009).

    2. González-Sarrías, A., Li, L., and Seeram, N.P. Anticancer effects of maple syrup phenolics and extracts on proliferation, apoptosis, and cell cycle arrest of human colon cells. J. Funct. Foods 4(1), 185-196 (2012).

    3. Huang, C.-H., Chen, M.-F., Chung, H.-H., et al. Antihyperglycemic effect of syringaldehyde in streptozotocin-induced diabetic rats. J. Nat. Prod. 75(8), 1465-1468 (2012).

    4. Shahzad, S., Mateen, S., Mariyath, P.M.M., et al. Protective effect of syringaldehyde on biomolecular oxidation, inflammation and histopathological alterations in isoproterenol induced cardiotoxicity in rats. Biomed. Pharmacother. 108, 625-633 (2018).