Sulfuretin

Sulfuretin is a flavonoid that has been found in R. verniciflua and has diverse biological activities.^1,2,3 It inhibits mushroom tyrosinase activity (IC₅₀ = 13.64 µM).¹ Sulfuretin decreases cytotoxicity induced by infectious hematopoietic necrosis virus (IHNV) in JFSP cells and viral hemorrhagic septicemia virus (VHSV) in CHSE-214 cells (EC₅₀s = 178.2 and 197.3 µM, respectively).² It decreases eosinophil, macrophage, and lymphocyte infiltration and reduces the levels of TNF-α, IL-5, IL-13, and CCL11 in bronchoalveolar lavage fluid (BALF), as well as inhibits methacholine-induced bronchoconstriction, in a mouse model of ovalbumin-induced asthma when administered at a dose of 40 µg/kg.³

WARNING This product is not for human or veterinary use.

1. Chen, H., Wang, C., Ye, J., et al. Isolation of sulfuretin and butin from Rhus verniciflua stokes using medium-pressure liquid chromatography and their tyrosinase inhibitory effects. Bioresources 11(1), 759-771 (2016).

2. Kang, S.Y., Kang, J.-Y., and Oh, M.-J. Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses in vitro. J. Microbiol. 50(2), 293-300 (2012).

3. Song, M.-Y., Jeong, G.-S., Lee, H.-S., et al. Sulfuretin attenuates allergic airway inflammation in mice. Biochem. Biophys. Res. Commun. 400(1), 83-88 (2010).