Bergaptol

Bergaptol is a furanocoumarin that has been found in A. dahurica and has diverse biological activities.^1,2,3,4 It inhibits the cytochrome P450 (CYP) isoform CYP3A4 (IC₅₀ = 24.92 µM).² It scavenges DPPH (Item No. 14805) and ABTS (Item No. 27317) radicals in cell-free assays (EC₅₀s = 26.66 and 13.55 µg/ml, respectively).¹ Bergaptol reduces the replication of L. donovani, T. b. brucei, and T. cruzi in L6 myoblasts (IC₅₀s = 2.5, 22.1, and 68 µg/ml, respectively).³ It induces cell cycle arrest at the S phase and apoptosis in MCF-7 breast cancer cells in a concentration-dependent manner.⁴ Bergaptol also decreases the proliferation of HeLa cervical carcinoma and HepG2 liver cancer cells (IC₅₀s = 58.57 and 68.42 µM, respectively).¹

WARNING This product is not for human or veterinary use.

1. Bai, Y., Li, D., Zhou, T., et al. Coumarins from the roots of Angelica dahurica with antioxidant and antiproliferative activities. J. Funct. Foods 20, 453-462 (2016).

2. Girennavar, B., Jayaprakasha, G.K., Jadegoud, Y., et al. Radical scavenging and cytochrome P450 3A4 inhibitory activity of bergaptol and geranylcoumarin from grapefruit. Bioorg. Med. Chem. 15(11), 3684-3691 (2007).

3. Tasdemir, D., Kaiser, M., Brun, R., et al. Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: In vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies. Antimicrob. Agents Chemother. 50(4), 1352-1364 (2006).

4. Ge, Z.-C., Qu, X., Yu, H.-F., et al. Antitumor and apoptotic effects of bergaptol are mediated via mitochondrial death pathway and cell cycle arrest in human breast carcinoma cells. Bangladesh J. Pharmacol. 11(2), 489-494 (2016).