A FFAR/GPR40 agonist and GPR84 antagonist
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PBI-4050 (sodium salt)

Item No. 42912

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
2-(3-pentylphenyl)acetate, monosodium salt
Molecular Formula
C13H18O2 • Na
Formula Weight
229.3
Purity
≥98%
Formulation (Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Sparingly soluble: 1-10 mg/mlPBS (pH 7.2): Sparingly soluble: 1-10 mg/ml
SMILES
O=C(CC1=CC=CC(CCCCC)=C1)[O-].[Na+]
InChi Code
InChI=1S/C13H18O2.Na/c1-2-3-4-6-11-7-5-8-12(9-11)10-13(14)15;/h5,7-9H,2-4,6,10H2,1H3,(H,14,15);/q;+1/p-1
InChi Key
CNSJWSLXKSJQFE-UHFFFAOYSA-M
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
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    5 mg

    $109

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    10 mg

    $196

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    25 mg

    $355

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    50 mg

    $545

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    Cayman Chemical
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    OBESITY RESEARCH SOLUTIONS
    Product Description

    PBI-4050 is an agonist of free fatty acid receptor 1 (FFAR1/GPR40) and an antagonist of G protein-coupled receptor 84 (GPR84).1 It induces β-arrestin-2 recruitment in a reporter assay using HEK293 cells expressing human FFAR1/GPR40 (EC50 = 275 µM). PBI-4050 inhibits activation of GPR84 induced by decanoic acid (Item No. 20838) or embelin (Item No. 11838) in reporter assays using HEK293 cells expressing the human receptor (IC50s = 398 and 209 µM, respectively). In vivo, PBI-4050 (200 mg/kg) decreases renal histological lesion scores in a mouse model of doxorubicin-induced nephrotoxicity. It also reduces tissue fibrosis in several additional in vivo rodent models, including carbon tetrachloride-induced hepatotoxicity and bleomycin-induced pulmonary fibrosis. PBI-4050 (100 mg/kg) decreases albuminuria, prevents decreases in the glomerular filtration rate (GFR) and podocyte numbers, and reduces blood glucose levels in a model of accelerated type 2 diabetes using eNos-/- db/db mice.2

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Gagnon, L., Leduc, M., J.-F., T., et al. A newly discovered antifibrotic pathway regulated by two fatty acid receptors: GPR40 and GPR84. Am. J. Pathol. 188(5), 1132-1148 (2018).

    2. Li, Y., Chung, S., Li, Z., et al. Fatty acid receptor modulator PBI-4050 inhibits kidney fibrosis and improves glycemic control. JCI Insight 3(10), e120365 (2018).