A peptide fragment of substance P
Technical Support & Resources

Information provided in the product description is from published literature. Due to the nature of scientific experimentation, your results (e.g., selectivity and effective concentrations) or specific application for this product may differ. If you have questions about how this product fits your application, please contact our technical support staff.

Visit our FAQ

Contact Us

Toll Free Phone (USA and Canada Only): (888) 526-5351
Direct Phone: (734) 975-3888

Request Technical Support

Technical Support Request

To streamline the process attach the appropriate questionnaire to your inquiry.

Download IHC QuestionnaireDownload WB Questionnaire

View Our Privacy Statement for details on how we use and protect your data. In addition, this site is protected by hCaptcha and its Privacy Policy and Terms of Service apply.

Substance P (1-7) (trifluoroacetate salt)

Item No. 43046

Product Insert (PDF)Safety Data Sheet (SDS) (PDF)
Technical Information
Formal Name
L-arginyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanine
Synonyms
  • Arg-Pro-Lys-Pro-Gln-Gln-Phe
  • SP (1-7)
Molecular Formula
C41H65N13O10 • XCF3COOH
Formula Weight
900.0
Purity
≥98%
Formulation (Request formulation change)
A solid
Peptide Sequence
RPKPQQF-OH
Solubility(Learn about Variance in Solubility)
DMSO: Sparingly soluble: 1-10 mg/mlEthanol: Slightly soluble: 0.1-1 mg/mlPBS (7.2 pH): Sparingly soluble: 1-10 mg/ml
SMILES
O=C([C@H]1N(C([C@@H](NC([C@H]2N(C([C@@H](N)CCCNC(N)=N)=O)CCC2)=O)CCCCN)=O)CCC1)N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@H](C(O)=O)CC3=CC=CC=C3)=O)=O.OC(C(F)(F)F)=O
InChi Code
InChI=1S/C41H65N13O10.C2HF3O2/c42-19-5-4-12-28(51-37(60)30-13-7-21-53(30)38(61)25(43)11-6-20-48-41(46)47)39(62)54-22-8-14-31(54)36(59)50-27(16-18-33(45)56)34(57)49-26(15-17-32(44)55)35(58)52-29(40(63)64)23-24-9-2-1-3-10-24;3-2(4,5)1(6)7/h1-3,9-10,25-31H,4-8,11-23,42-43H2,(H2,44,55)(H2,45,56)(H,49,57)(H,50,59)(H,51,60)(H,52,58)(H,63,64)(H4,46,47,48);(H,6,7)/t25-,26-,27-,28-,29-,30-,31-;/m0./s1
InChi Key
NGJNGAVSGJSPNQ-OSSAIMHMSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room temperature in continental US; may vary elsewhere
Recommended Products

Certificates of Analysis & Batch Specific Data

Provide batch numbers separated by commas to download or request available product inserts, QC sheets, certificates of analysis, data packs, and GC-MS data.

Download most recent Certificate of Analysis for this product

    1 mg

    $28

    Add

    5 mg

    $125

    Add

    10 mg

    $207

    Add

    25 mg

    $379

    Add
    Product Description

    Substance P (1-7) is a peptide fragment of the neuropeptide substance P (Item No. 24035).1 It is produced by proteolytic cleavage of substance P by neprilysin. Substance P (1-7) (10 nM) induces internalization of the neurokinin-1 (NK1) receptor in isolated rat striatal slices.2 It inhibits substance P-induced contralateral rotation in rats and substance P-induced substantia nigra dopamine release in anesthetized rats.3 Administration of substance P (1-7) into the nucleus tractus solitarius decreases mean arterial pressure and heart rate in anesthetized rats.1 Substance P (1-7) (1 nmol/animal) reduces withdrawal jumping in morphine-dependent mice when administered intrathecally.4 It increases the latency to tail-flick in the tail-flick test in streptozotocin-induced diabetic mice, an effect that can be reversed by naloxone or (+)-pentazocine but not naltrindole (Item No. 9000705), β-funaltrexamine (Item No. 39901), norbinaltorphimine, or BD 1047 (Item No. 22928).5 Substance P (1-7) (35 pmol/animal) increases the number of entries into and percentage of time spent in the open arms of the elevated plus maze in rats, indicating anxiolytic-like activity.6

    WARNING This product is not for human or veterinary use.

    References & Product Citations
    Product Description References

    1. Hall, M.E., Miley, F., and Stewart, J.M. The role of enzymatic processing in the biological actions of substance P. Peptides 10(4), 895-901 (1989).

    2. Michael-Titus, A.T., Blackburn, D., Connolly, Y., et al. N- and C-terminal substance P fragments: Differential effects on striatal [3H]substance P binding and NK1 receptor internalization. Neuroreport 13(10), 2209-2213 (1999).

    3. Herrera-Marschitz, M., Terenius, L., Sakurada, T., et al. The substance P(1-7) fragment is a potent modulator of substance P actions in the brain. Brain Res. 521(1-2), 316-320 (1990).

    4. Kreeger, J.S., and Larson, A.A. Substance P-(1-7), a substance P metabolite, inhibits withdrawal jumping in morphine-dependent mice. Eur. J. Pharmacol. 238(1), 111-115 (1993).

    5. Carlsson, A., Ohsawa, M., Hallberg, M., et al. Substance P(1-7) induces antihyperalgesia in diabetic mice through a mechanism involving the naloxone-sensitive sigma receptors. Eur. J. Pharmacol. 626(2-3), 250-255 (2010).

    6. De Araújo, J.E., Huston, J.P., and Brandão, M.L. Opposite effects of substance P fragments C (anxiogenic) and N (anxiolytic) injected into dorsal periaqueductal gray. Eur. J. Pharmacol. 432(1), 43-51 (2001).